Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer
| Title: | Compartment-specific tumor-infiltrating immune cells and prognosis in breast cancer |
|---|---|
| Authors: | Aaron J. Bernstein; Renske Keeman; Amber N. Hurson; Fiona M. Blows; Manjeet K. Bolla; Jodi L. Miller; Roger L. Milne; Hugo Horlings; Alexandra J. van den Broek; Clara Bodelon; James M. Hodge; Alpa V. Patel; Lauren R. Teras; Federico Canzian; Rudolf Kaaks; Hermann Brenner; Ben Schöttker; Sabine Behrens; Jenny Chang-Claude; Tabea Maurer; Nadia Obi; Fergus J. Couch; H. Raza Ali; Carlos Caldas; Irene Andrulis; Gord Glendon; Anna Marie Mulligan; Wilma Mesker; Agnes Jager; Annette Heemskerk-Gerritsen; Peter Devilee; Scott M. Lawrence; Jolanta Lissowska; Karun Mutreja; Thomas Ahearn; Stephen Chanock; Maire A. Duggan; Diana Eccles; J. Louise Jones; Will Tapper; Antoinette Hollestelle; Maartje Hooning; John Martens; Carolien H.M. van Deurzen; Angela Cox; Simon S. Cross; Mikael Hartman; Jingmei Li; Thomas C. Putti; Ute Hamann; Muhammad Rashid; Ania Jakubowska; Nicki Camp; Melissa H. Cessna; Amy Berrington de Gonzalez; Katarzyna Bialkowska; Jacek Gronwald; Jan Lubiński; Siddhartha Yadav; Pietro Lio; Douglas F. Easton; Mustapha Abubakar; Montse Garcia-Closas; Paul D.P. Pharoah; Marjanka K. Schmidt |
| Source: | iScience, Vol 29, Iss 2, Pp 114759- (2026) |
| Publisher Information: | Elsevier |
| Publication Year: | 2026 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Oncology; Immunology; Artificial intelligence; Science |
| Description: | Summary: Breast cancer immune response is important to patient outcome, but the prognostic interaction between tissue-infiltrating immune cell (TIIC) types is not well-characterized. We evaluated the associations between CD8+, FOXP3+, CD20+, and CD163+ TIICs and breast cancer-specific survival (BCSS). We developed an AI in Halo to score TIIC percentage by compartment (overall, stromal, or intra-tumoral) in 99,051 microarray images from 12,285 female breast cancers. The associations between log-transformed TIIC scores and BCSS were assessed using Cox regression. CD8+ and FOXP3+ TIICs were associated with better BCSS in ER-negative disease; CD8+ and CD20+ TIICs were associated with a better prognosis in ER-positive disease; and CD163+ TIICs were associated with a poorer prognosis in ER-positive disease in multi-marker models. These results may have implications for breast cancer immunotherapy. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2589004226001343; https://doaj.org/toc/2589-0042; https://doaj.org/article/853d18b8e47f45ef9c2d4cd313621bd1 |
| DOI: | 10.1016/j.isci.2026.114759 |
| Availability: | https://doi.org/10.1016/j.isci.2026.114759; https://doaj.org/article/853d18b8e47f45ef9c2d4cd313621bd1 |
| Accession Number: | edsbas.D9C931C4 |
| Database: | BASE |