| Title: |
The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals without Gastrointestinal Inflammation |
| Authors: |
Nelson, A; Stewart, CJ; Kennedy, NA; Lodge, JK; Tremelling, M; Probert, CS; Parkes, M; Mansfield, JC; Smith, DL; Hold, GL; Lees, CW; Bridge, SH; Lamb, CA |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2021 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Background and Aims: Historical and emerging data implicate fungi in Crohn's disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate associations between NOD2 variants and faecal mycobiota in CD patients and non-CD subjects. Methods: Faecal samples were obtained from 34 CD patients [18 NOD2 mutant, 16 NOD2 wild-type] identified from the UK IBD Genetics Consortium. To avoid confounding influence of mucosal inflammation, CD patients were in clinical remission and had a faecal calprotectin |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1873-9946 |
| Relation: |
https://livrepository.liverpool.ac.uk/3109624/1/jjaa220%20-%20myocbiome%20genome%20JCC.pdf; Collapse authors list. Nelson, A, Stewart, CJ, Kennedy, NA, Lodge, JK, Tremelling, M, Probert, CS, Parkes, M, Mansfield, JC, Smith, DL, Hold, GL et al (show 3 more authors) , Lees, CW, Bridge, SH and Lamb, CA (2021) The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals without Gastrointestinal Inflammation Journal of Crohn S and Colitis, 15 (5). pp. 800-812. ISSN 1873-9946, 1876-4479 |
| DOI: |
10.1093/ecco-jcc/jjaa220 |
| Availability: |
https://livrepository.liverpool.ac.uk/3109624/; https://doi.org/10.1093/ecco-jcc/jjaa220 |
| Accession Number: |
edsbas.DA3AF67D |
| Database: |
BASE |