| Title: |
Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls |
| Authors: |
Simone B; De Stefano V; Leoncini E; Zacho J; Martinelli I; Emmerich J; Rossi E; Folsom AR; Almawi WY; Scarabin PY; den Heijer M; Cushman M; Penco S; Vaya A; Angchaisuksiri P; Okumus G; GEMMATI, Donato; Cima S; Akar N; Oguzulgen KI; Ducros V; Lichy C; Fernandez Miranda C; Szczeklik A; Nieto JA; Torres JD; Le Cam Duchez V; Ivanov P; Cantu Brito C; Shmeleva VM; Stegnar M; Ogunyemi D; Eid SS; Nicolotti N; De Feo E; Ricciardi W; Boccia S. |
| Contributors: |
Simone, B; De Stefano, V; Leoncini, E; Zacho, J; Martinelli, I; Emmerich, J; Rossi, E; Folsom, Ar; Almawi, Wy; Scarabin, Py; den Heijer, M; Cushman, M; Penco, S; Vaya, A; Angchaisuksiri, P; Okumus, G; Gemmati, Donato; Cima, S; Akar, N; Oguzulgen, Ki; Ducros, V; Lichy, C; Fernandez Miranda, C; Szczeklik, A; Nieto, Ja; Torres, Jd; Le Cam Duchez, V; Ivanov, P; Cantu Brito, C; Shmeleva, Vm; Stegnar, M; Ogunyemi, D; Eid, S; Nicolotti, N; De Feo, E; Ricciardi, W; Boccia, S. |
| Publication Year: |
2013 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: |
Factor V Leiden; Genetic susceptibility; Methylenetetrahydrofolate reductase C677T; Prothrombin G202010A; Venous thromboembolism; thromboembolism; combined defects; Prothrombin 20210A; MTHFR C677T; meta-analysis |
| Description: |
Genetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden, FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies. We performed a pooled analysis of case-control and cohort studies investigating in adults the association between each variant and VTE, published on Pubmed, Embase or Google through January 2010. Authors of eligible papers, were invited to provide all available individual data for the pooling. The Odds Ratio (OR) for first VTE associated with each variant, individually and combined with the others, were calculated with a random effect model, in heterozygotes and homozygotes (dominant model for FVL and PT20210A; recessive for C677T MTHFR). We analysed 31 databases, including 11,239 cases and 21,521 controls. No significant association with VTE was found for h. ; Genetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden, FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies. We performed a pooled analysis of case–control and cohort studies investigating in adults the association between each variant and VTE, published on Pubmed, Embase or Google through January 2010. Authors of eligible papers, were invited to provide all available individual data for the pooling. The Odds Ratio (OR) for first VTE associated with each variant, individually and combined with the others, were calculated with a random effect model, in heterozygotes and homozygotes (dominant model for FVL and PT20210A; recessive for C677T MTHFR). We analysed 31 databases, including 11,239 cases and 21,521 controls. No significant association with VTE was found for homozygous C677T MTHFR (OR: 1.38; 95 % ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/23900608; info:eu-repo/semantics/altIdentifier/wos/WOS:000324321700002; volume:28; issue:8; firstpage:621; lastpage:647; numberofpages:27; journal:EUROPEAN JOURNAL OF EPIDEMIOLOGY; https://hdl.handle.net/11392/1834701 |
| DOI: |
10.1007/s10654-013-9825-8 |
| Availability: |
https://hdl.handle.net/11392/1834701; https://doi.org/10.1007/s10654-013-9825-8; https://link.springer.com/article/10.1007/s10654-013-9825-8 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:NON PUBBLICO - Accesso privato/ristretto ; license:PUBBLICO - Pubblico con Copyright ; license uri:iris.PRI01 ; license uri:iris.PUB02 |
| Accession Number: |
edsbas.DA3C464B |
| Database: |
BASE |