| Title: |
Acoel genome reveals the regulatory landscape of whole-body regeneration |
| Authors: |
Gehrke, Andrew R.; Neverett, Emily; Luo, Yi-Jyun; Brandt, Alexander; Ricci, Lorenzo; Hulett, Ryan E.; Gompers, Annika; Ruby, J. Graham; Rokhsar, Daniel S.; Reddien, Peter W.; Srivastava, Mansi |
| Contributors: |
National Science Foundation; Searle Scholars Program |
| Source: |
Science ; volume 363, issue 6432 ; ISSN 0036-8075 1095-9203 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2019 |
| Description: |
Acoel-regeneration regulatory landscapes Some animals, including some types of worms, can undergo whole-body regeneration and replace virtually any missing cell type. Gehrke et al. sequenced and assembled the genome of Hofstenia miamia , a regenerative acoel worm species (see the Perspective by Alonge and Schatz). They identified a variable motif corresponding to regulation of the early growth response ( egr ) gene that was involved in regeneration. RNA interference experiments and validation in a second species showed that the protein Egr is a pioneer factor that stimulates regeneration. Science , this issue p. eaau6173 ; see also p. 1152 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/science.aau6173 |
| Availability: |
https://doi.org/10.1126/science.aau6173; https://syndication.highwire.org/content/doi/10.1126/science.aau6173; https://www.science.org/doi/pdf/10.1126/science.aau6173 |
| Accession Number: |
edsbas.DA3C5ADC |
| Database: |
BASE |