| Title: |
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts |
| Authors: |
Moll, M; Sakornsakolpat, P; Shrine, N; Hobbs, BD; DeMeo, DL; John, C; Guyatt, AL; McGeachie, MJ; Gharib, SA; Obeidat, M; Lahousse, L; Wijnant, SRA; Brusselle, G; Meyers, DA; Bleecker, ER; Li, X; Tal-Singer, R; Manichaikul, A; Rich, SS; Won, S; Kim, WJ; Do, AR; Washko, GR; Barr, RG; Psaty, BM; Bartz, TM; Hansel, NN; Barnes, K; Hokanson, JE; Crapo, JD; Lynch, D; Bakke, P; Gulsvik, A; Hall, IP; Wain, L; Soler Artigas, M; Jackson, VE; Strachan, DP; Hui, J; James, AL; Kerr, SM; Polasek, O; Vitart, V; Marten, J; Rudan, I; Kähönen, M; Surakka, I; Gieger, C; Karrasch, S; Rawal, R; Schulz, H; Deary, IJ; Harris, SE; Enroth, S; Gyllensten, U; Imboden, M; Probst-Hensch, NM; Lehtimäki, T; Raitakari, OT; Langenberg, C; Luan, J; Wareham, N; Zhao, JH; Hayward, C; Murray, A; Porteous, DJ; Smith, BH; Jarvelin, MR; Wielscher, M; Joshi, PK; Kentistou, KA; Timmers, PR; Wilson, JF; Cook, JP; Lind, L; Mahajan, A; Morris, AP; Ewert, R; Homuth, G; Stubbe, B; Weiss, S; Zeggini, E; Weiss, ST; Silverman, EK; Dudbridge, F; Tobin, MD; Cho, MH |
| Publisher Information: |
ELSEVIER SCI LTD |
| Publication Year: |
2020 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. METHODS: We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2213-2600 |
| Relation: |
https://hdl.handle.net/11343/252490 |
| Availability: |
https://hdl.handle.net/11343/252490 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.DA425327 |
| Database: |
BASE |