| Title: |
Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats |
| Authors: |
Pennisi, Maria Grazia (University of Messina); Hosie, Margaret J. (University of Glasgow); Egberink, Herman (University of Utrecht); Boucraut-Baralon, Corine (Scanelis Laboratory); Addie, Diane D.; Belák, Sándor (Swedish University of Agricultural Sciences); Tasker, Séverine (University of Bristol / Linnaeus Veterinary Limited); Möstl, Karin (University of Veterinary Medicine Vienna); Truyen, Uwe (University of Leipzig); Thiry, Etienne (Liège University); Marsilio, Fulvio (Università degli Studi di Teramo); Lloret, Albert (Universitat Autònoma de Barcelona); Hofmann-Lehmann, Regina (University of Zurich); Hartmann, Katrin (Ludwig Maximilian University of Munich); Frymus, Tadeusz (Warsaw University of Life Sciences) |
| Source: |
Viruses 15(10) (2023) |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Subject Terms: |
Domestic Cats; 1st Report; Distemper; Lions; Frequency; Kidneys; Lesions; Urine |
| Description: |
Feline morbillivirus (FeMV) was first isolated in 2012 from stray cats in Hong Kong. It has been found in association with tubulointerstitial nephritis (TIN), the most common cause of feline chronic kidney disease (CKD). However, viral host spectrum and virus tropism go beyond the domestic cat and kidney tissues. The viral genetic diversity of FeMV is extensive, but it is not known if this is clinically relevant. Urine and kidney tissues have been widely tested in attempts to confirm associations between FeMV infection and renal disease, but samples from both healthy and sick cats can test positive and some cross-sectional studies have not found associations between FeMV infection and CKD. There is also evidence for acute kidney injury following infection with FeMV. The results of prevalence studies differ greatly depending on the population tested and methodologies used for detection, but worldwide distribution of FeMV has been shown. Experimental studies have confirmed previous field observations that higher viral loads are present in the urine compared to other tissues, and renal TIN lesions associated with FeMV antigen have been demonstrated, alongside virus lymphotropism and viraemia-associated lymphopenia. Longitudinal field studies have revealed persistent viral shedding in urine, although infection can be cleared spontaneously. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publications]; https://phaidra.vetmeduni.ac.at/o:2526 |
| DOI: |
10.3390/v15102087 |
| Availability: |
https://doi.org/10.3390/v15102087; https://phaidra.vetmeduni.ac.at/o:2526 |
| Rights: |
CC BY 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.DA4A0538 |
| Database: |
BASE |