| Title: |
Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoSI Registry |
| Authors: |
Corrao, Salvatore; Nobili, Alessandro; Natoli, Giuseppe; Mannucci, Pier Mannuccio; Perticone, Francesco; Pietrangelo, Antonello; Argano, Christiano; REPOSI Investigators; Zanetti, Michela |
| Contributors: |
Corrao, Salvatore; Nobili, Alessandro; Natoli, Giuseppe; Mannucci, Pier Mannuccio; Perticone, Francesco; Pietrangelo, Antonello; Argano, Christiano; Reposi, Investigator; Zanetti, Michela |
| Publication Year: |
2021 |
| Collection: |
Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| Subject Terms: |
Comorbidity; Diabete; Disability; Elderly; Hyperglycemia; Mortality |
| Description: |
Aims The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged >= 65 years. Methods Data were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), renal function, functional (Barthel Index), and cognitive status (Short Blessed Test) and mood disorders (Geriatric Depression Scale) were recorded. Mortality rates were assessed in hospital 3 and 12 months after discharge. Results Of the 4714 elderly patients hospitalized, 361 had a glycemia level >= 250 mg/dL at admission. Compared to subjects with lower glycemia level, patients with glycemia >= 250 mg/dL showed higher rates of male sex, smoke and class III obesity. These patients had a significantly lower Barthel Index (p = 0.0249), higher CIRS-SI and CIRS-CI scores (p = 0.0025 and p = 0.0013, respectively), and took more drugs. In-hospital mortality rate was 9.2% and 5.1% in subjects with glycemia >= 250 and < 250 mg/dL, respectively (p=0.0010). Regression analysis showed a strong association between in-hospital death and glycemia >= 250 mg/dL (OR 2.07; [95% CI 1.34-3.19]), Barthel Index = 250 mg/dL, Barthel Index |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33890176; info:eu-repo/semantics/altIdentifier/wos/WOS:000642358500001; volume:58; issue:9; firstpage:1225; lastpage:1236; numberofpages:12; journal:ACTA DIABETOLOGICA; https://hdl.handle.net/11368/3052967; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316168/ |
| DOI: |
10.1007/s00592-021-01716-8 |
| Availability: |
https://hdl.handle.net/11368/3052967; https://doi.org/10.1007/s00592-021-01716-8; https://link.springer.com/article/10.1007/s00592-021-01716-8; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316168/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.DA5E1EDB |
| Database: |
BASE |