Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection
| Title: | Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection |
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| Authors: | E. Chiappini; L. Galli; P. A. Tovo; C. Gabiano; M. de Martino; P. Osimani; R. Cordiali; D. De Mattia; M. Manzionna; C. Di Bari; M. Ruggeri; M. Masi; A. Miniaci; F. Specchia; M. Ciccia; M. Lanari; F. Baldi; L. Battisti; C. Fiorino; C. Dessı`; C. Pintor; M. Dedoni; M. L. Fenu; R. Cavallini; E. Anastasio; F. Merolla; M. Sticca; G. Pomero; F. Bonsignori; P. Gervaso; E. Seini; M. T. Cecchi; D. Cosso; A. Timitilli; M. Stronati; A. Plebani; R. Pinzani; I. Bongianin; A. Vigano`; V. Giacomet; P. Erba; F. Salvini; G. V. Zuccotti; M. Giovannini; G. Ferraris; R. Lipreri; C. Moretti; M. Cellini; M. C. Cano; P. Paolucci; E. Bruzzese; G. De Marco; L. Tarallo; F. Tancredi; M. Pennazzato; O. Rampon; E. R. Dalle Nogare; A. Sanfilippo; A. Romano; M. Saitta; I. Dodi; A. Barone; A. Maccabruni; R. Consolini; A. Legitimo; C. Magnani; P. Falconieri; C. Fundaro`; O. Genovese; A. Panzanella; A. M. Casadei; A. Martino; C. Concato; G. Anzidei; G. Bove; S. Cerilli; S. Catania; C. Ajassa; A. Ganau; L. Cristiano; A. Mazza; A. Di Palma; F. Mignone; C. Riva; C. Scorfaro; V. Portelli; M. Rabusin; A. Pellegatta; M. Molesini; BEZZI, Teresa Maria; FIUMANA, Elisa |
| Contributors: | E., Chiappini; L., Galli; P. A., Tovo; C., Gabiano; M., de Martino; P., Osimani; R., Cordiali; D., De Mattia; M., Manzionna; C., Di Bari; M., Ruggeri; M., Masi; A., Miniaci; F., Specchia; M., Ciccia; M., Lanari; F., Baldi; L., Battisti; C., Fiorino; C., Dessı`; C., Pintor; M., Dedoni; M. L., Fenu; R., Cavallini; E., Anastasio; F., Merolla; M., Sticca; G., Pomero; Bezzi, Teresa Maria; Fiumana, Elisa; F., Bonsignori; P., Gervaso; E., Seini; M. T., Cecchi; D., Cosso; A., Timitilli; M., Stronati; A., Plebani; R., Pinzani; I., Bongianin; A., Vigano`; V., Giacomet; P., Erba; F., Salvini; G. V., Zuccotti; M., Giovannini; G., Ferrari; R., Lipreri; C., Moretti; M., Cellini; M. C., Cano; P., Paolucci; E., Bruzzese; G., De Marco; L., Tarallo; F., Tancredi; M., Pennazzato; O., Rampon; E. R., Dalle Nogare; A., Sanfilippo; A., Romano; M., Saitta; I., Dodi; A., Barone; A., Maccabruni; R., Consolini; A., Legitimo; C., Magnani; P., Falconieri; C., Fundaro`; O., Genovese; A., Panzanella; A. M., Casadei; A., Martino; C., Concato; G., Anzidei; G., Bove; S., Cerilli; S., Catania; C., Ajassa; A., Ganau; L., Cristiano; A., Mazza; A., Di Palma; F., Mignone; C., Riva; C., Scorfaro; V., Portelli; M., Rabusin; A., Pellegatta; M., Molesini |
| Publication Year: | 2005 |
| Collection: | Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: | HIV-1 infection; combinedantiretroviral therapy; hyper-IgA |
| Description: | Non-expensive and low-complexity surrogate markers for monitoring the response to combined antiretroviral therapy (combined-ART) are needed in poor-resource settings where routine assessment of CD4+ T-lymphocyte count and viral load can not be afforded. We longitudinally evaluated Ig serum levels in 234 HIV-1 infected children receiving combined-ART with ≥ 3 drugs. Since Ig levels physiologically vary with age, differences at different age periods were evaluated as differences in z-scores calculated using the mean and standard deviation of the normal population for each age period. Data from 17 (7·3%) children with immunological failure and from 54 (23·1%) children with virological failure of combined-ART were compared with data from not-failed children. At baseline children with immunological failure showed higher IgM z-scores (P = 0·042) than children without. After 3–12 months of therapy immunologically failed children displayed higher viral loads (P < 0·0001) and IgA (P = 0·043) z-scores than not-failed children. Similarly, at the same follow-up time, children with virological failure showed lower CD4+ T-lymphocyte percentages (P = 0·005) and higher IgA z-scores (P < 0·0001) than not-failed children. No difference in IgG or IgM z-scores was evidenced between failed and not-failed children after 3–12 months of therapy. In conclusion, IgA serum level is a cheap and low-complexity marker of immunological or virological failure of combined-ART which might be adopted in poor-resource settings. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000227968900016; volume:140; issue:2; firstpage:320; lastpage:324; journal:CLINICAL AND EXPERIMENTAL IMMUNOLOGY; https://hdl.handle.net/11392/522627 |
| DOI: | 10.1111/j.1365-2249.2005.02756.x |
| Availability: | https://hdl.handle.net/11392/522627; https://doi.org/10.1111/j.1365-2249.2005.02756.x |
| Accession Number: | edsbas.DA9E6326 |
| Database: | BASE |