| Title: |
Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index |
| Authors: |
Renehan, Andrew; Harriss, D. J.; Atkinson, G.; George, K.; Tim Cable, N.; Reilly, T.; Haboubi, N.; Zwahlen, M.; Egger, M.; Renehan, A. G. |
| Source: |
Renehan, A, Harriss, D J, Atkinson, G, George, K, Tim Cable, N, Reilly, T, Haboubi, N, Zwahlen, M, Egger, M & Renehan, A G 2009, 'Lifestyle factors and colorectal cancer risk (1): Systematic review and meta-analysis of associations with body mass index', Colorectal Disease, vol. 11, no. 6, pp. 547-563. https://doi.org/10.1111/j.1463-1318.2009.01766.x |
| Publication Year: |
2009 |
| Collection: |
The University of Manchester: Research Explorer - Publications |
| Subject Terms: |
Body mass index; Colorectal cancer risk; Obesity; Systematic review |
| Description: |
Objective: Excess body weight, defined by body mass index (BMI), may increase the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we undertook a systematic review and meta-analysis of prospective observational studies to quantify colorectal cancer risk associated with increased BMI and explore for differences by gender, sub-site and study characteristics. Method: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. Random-effects meta-analyses and meta-regressions of study-specific incremental estimates were performed to determine the risk ratio (RR) and 95% confidence intervals (CIs) associated with a 5 kg/m2 increase in BMI. Results: We analysed 29 datasets from 28 articles, including 67361 incident cases. Higher BMI was associated with colon (RR 1.24, 95% CIs: 1.20-1.28) and rectal (1.09, 1.05-1.14) cancers in men, and with colon cancer (1.09, 1.04-1.12) in women. Associations were stronger in men than in women for colon (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1462-8910; 1463-1318 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/1462-8910; info:eu-repo/semantics/altIdentifier/eissn/1463-1318 |
| DOI: |
10.1111/j.1463-1318.2009.01766.x |
| Availability: |
https://research.manchester.ac.uk/en/publications/845c0e36-1704-4782-b939-6f8b3366038c; https://doi.org/10.1111/j.1463-1318.2009.01766.x |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.DACF3DC7 |
| Database: |
BASE |