| Title: |
POS0834 Long-Term Outcome of SSC Associated ILD: Improved Survival in PPI Treated Patients |
| Authors: |
Kreuter, M.; Bonella, F.; Kathrin, K.; Henes, J.; Siegert, E.; Riemekasten, G.; Blank, N.; Pfeiffer, C.; Müller-Ladner, U.; Kreuter, A.; Hunzelmann, N. |
| Contributors: |
Kreuter, M.; Bonella, F.; Kathrin, K.; Henes, J.; Siegert, E.; Riemekasten, G.; Blank, N.; Pfeiffer, C.; Müller-Ladner, U.; Kreuter, A.; Hunzelmann, N. |
| Publication Year: |
2021 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
Background: Gastroesophageal reflux disease (GERD) occurs frequently in patients with systemic sclerosis (SSc) and SSc-associated interstitial lung disease (SSc-ILD). PPI use has to been shown to improve survival in patients with idiopathic pulmonary fibrosis, whereas to date there are no data on the use of PPI in SSc-ILD. Objectives: This study was aimed to assess whether use of PPI is associated with progression of SSc-ILD and survival. Methods: We retrospectively analysed 1931 patients with SSc and SSc-ILD from the German Network for Systemic Sclerosis (DNSS) database (2003 onwards). Kaplan–Meier analysis compared overall survival (OS) and progression-free survival (PFS) in patients with vs. without GERD (SSc and SSc-ILD), and PPI vs. no PPI use (SSc-ILD only). Progression was defined as a decrease in either % predicted forced vital capacity ≥10% or single-breath diffusing capacity for carbon monoxide ≥15%, or death. Results: GERD was not associated with decreased OS or PFS in patients with either SSc or SSc-ILD. In patients with SSc-ILD, PPI use was associated with improved OS vs. no PPI use after 1 year (98.4% [95% confidence interval: 97.6–99.3]; n=760 vs. 90.8% [87.9–93.8]; n=290) and after 5 years (91.4% [89.2–93.8]; n=357 vs. 70.9% [65.2–77.1]; n=106; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/annrheumdis-2021-eular.878 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/89991; https://doi.org/10.1136/annrheumdis-2021-eular.878 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.DAE7414B |
| Database: |
BASE |