| Title: |
Respiratory Syncytial Virus Hospital Admission Rates and Patients’ Characteristics Before the Age of 2 Years in England, 2015–2019 |
| Authors: |
Fonseca, Maria João; Hagenaars, Saskia; Bangert, Mathieu; Flach, Clare; Hudson, Richard D.A. |
| Source: |
Pediatric Infectious Disease Journal ; volume 43, issue 9, page 909-915 ; ISSN 0891-3668 1532-0987 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2024 |
| Description: |
Background: A granular understanding of respiratory syncytial virus (RSV) burden in England is needed to prepare for new RSV prevention strategies. We estimated the rates of RSV hospital admissions before the age of 2 years in England and described baseline characteristics. Methods: A birth cohort of all infants born between March 1, 2015, and February 28, 2017 (n = 449,591) was established using Clinical Practice Research Datalink-Hospital Episode Statistics. Case cohorts included infants with admission for (1) RSV, (2) bronchiolitis, (3) any respiratory tract infection (RTI) 54% were born before the RSV season. During the first year of life, 11.6 RSV-coded and 34.4 RSV-predicted hospitalizations occurred per 1000 person-years. Overall, >25% of unspecified lower RTI admissions were estimated to be due to RSV. Conclusions: In England, 1 in 91 infants had an RSV-coded admission, likely underestimated by ~3-fold. Most infants were term-healthy infants born before the RSV season. To decrease the total burden of RSV at the population level, immunization programs need to protect all infants. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/inf.0000000000004467 |
| DOI: |
10.1097/INF.0000000000004467 |
| Availability: |
https://doi.org/10.1097/inf.0000000000004467; https://journals.lww.com/10.1097/INF.0000000000004467 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.DB138FF |
| Database: |
BASE |