Katalog Plus
Bibliothek der Frankfurt UAS
Bald neuer Katalog: sichern Sie sich schon vorab Ihre persönlichen Merklisten im Nutzerkonto: Anleitung.
Dieses Ergebnis aus BASE kann Gästen nicht angezeigt werden.  Login für vollen Zugriff.

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Title: Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Authors: Mills, Melinda C.; Tropf, Felix C.; Brazel, David M.; van Zuydam, Natalie; Vaez, Ahmad; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Andiappan, Anand Kumar; Arindrarto, Wibowo; Awadalla, Philip; Battle, Alexis; Beutner, Frank; Jan Bonder, Marc; Boomsma, Dorret I.; Christiansen, Mark W.; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; Frayling, Timothy; Gharib, Sina A.; Gibson, Greg; Heijmans, Bastiaan T.; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johannes; Kim, Yungil; Kirsten, Holger; Kovacs, Peter; Krohn, Knut; Kronberg, Jaanika; Kukushkina, Viktorija; Kutalik, Zoltan; Lee, Bernett; Lehtimäki, Terho; Loeffler, Markus; Marigorta, Urko M.; Mei, Hailang; Milani, Lili; Montgomery, Grant W.; Müller-Nurasyid, Martina; Nauck, Matthias; Nivard, Michel G.; Penninx, Brenda W. J. H.; Perola, Markus; Pervjakova, Natalia; Pierce, Brandon L.; Powell, Joseph; Prokisch, Holger; Psaty, Bruce M.; Raitakari, Olli T.; Ripatti, Samuli; Rotzschke, Olaf; Rüeger, Sina; Saha, Ashis; Scholz, Markus; Schramm, Katharina; Seppälä, Ilkka; Slagboom, Eline P.; Stehouwer, Coen D. A.; Stumvoll, Michael; Sullivan, Patrick; ‘t Hoen, Peter A. C.; Teumer, Alexander; Thiery, Joachim; Tong, Lin; Tönjes, Anke; van Dongen, Jenny; van Iterson, Maarten; van Meurs, Joyce; Veldink, Jan H.; Verlouw, Joost; Visscher, Peter M.; Völker, Uwe; Võsa, Urmo; Westra, Harm-Jan; Wijmenga, Cisca; Yaghootkar, Hanieh; Yang, Jian; Zeng, Biao; Zhang, Futao; Isaacs, Aaron; Pool, René; Jan Hottenga, Jouke; van Greevenbroek, Marleen M. J.; van der Kallen, Carla J. H.; Schalkwijk, Casper G.; Zhernakova, Sasha; Tigchelaar, Ettje F.; Beekman, Marian; Deelen, Joris; van Heemst, Diana; van den Berg, Leonard H.; van Duijn, Cornelia M.; Hofman, Bert A.; Uitterlinden, André G.; Jhamai, P. Mila; Verbiest, Michael; Suchiman, H. Eka D.; Verkerk, Marijn; van der Breggen, Ruud; van Rooij, Jeroen; Lakenberg, Nico; Mei, Hailiang; van Galen, Michiel; Bot, Jan; Zhernakova, Dasha V.; van ’t Hof, Peter; Nooren, Irene; Moed, Matthijs; Vermaat, Martijn; Luijk, René; van Dijk, Freerk; Kielbasa, Szymon M.; Swertz, Morris A.; van Zwet, Erik. W.; Akimova, Evelina T.; Bergmann, Sven; Boardman, Jason D.; Brumat, Marco; Buring, Julie E.; Cesarini, David; Chasman, Daniel I.; Chavarro, Jorge E.; Cocca, Massimiliano; Concas, Maria Pina; Davey-Smith, George; Davies, Gail; Deary, Ian J.; Franco, Oscar; Gaskins, Audrey J.; de Geus, Eco J. C.; Gieger, Christian; Girotto, Giorgia; Grabe, Hans Jörgen; Gunderson, Erica P.; Harris, Kathleen Mullan; Hartwig, Fernando P.; He, Chunyan; Hill, W. David; Homuth, Georg; Horta, Bernando Lessa; Huang, Hongyang; Hyppӧnen, Elina; Ikram, M. Arfan; Johannesson, Magnus; Kamali, Zoha; Kavousi, Maryam; Kraft, Peter; Kühnel, Brigitte; Langenberg, Claudia; Lind, Penelope A.; Luan, Jian’an; Mägi, Reedik; Magnusson, Patrik K. E.; Mahajan, Anubha; Martin, Nicholas G.; Mbarek, Hamdi; McCarthy, Mark I.; McMahon, George; McQueen, Matthew B.; Medland, Sarah E.; Meitinger, Thomas; Metspalu, Andres; Mihailov, Evelin; Missmer, Stacey A.; Møllegaard, Stine; Mook-Kanamori, Dennis O.; Morgan, Anna; van der Most, Peter J.; de Mutsert, Renée; Nolte, Ilja M.; Noordam, Raymond; Peters, Annette; Power, Chris; Redmond, Paul; Rich-Edwards, Janet W.; Ridker, Paul M.; Rietveld, Cornelius A.; Ring, Susan M.; Rose, Lynda M.; Rueedi, Rico; Stefánsson, Kári; Stöckl, Doris; Strauch, Konstantin; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Thurik, A. Roy; Timpson, Nicholas J.; Turman, Constance; Waldenberger, Melanie; Wareham, Nicholas J.; Willemsen, Gonneke; Zhao, Jing Hau; Pers, Tune H.; Snieder, Harold; Perry, John R. B.; Ong, Ken K.; den Hoed, Marcel; Barban, Nicola; Day, Felix R.
Contributors: Mills, Melinda C.; Tropf, Felix C.; Brazel, David M.; van Zuydam, Natalie; Vaez, Ahmad; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Andiappan, Anand Kumar; Arindrarto, Wibowo; Awadalla, Philip; Battle, Alexi; Beutner, Frank; Jan Bonder, Marc; Boomsma, Dorret I.; Christiansen, Mark W.; Claringbould, Annique; Deelen, Patrick; Esko, Tõnu; Favé, Marie-Julie; Franke, Lude; Frayling, Timothy; Gharib, Sina A.; Gibson, Greg; Heijmans, Bastiaan T.; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Anette; Kasela, Silva; Kettunen, Johanne; Kim, Yungil; Kirsten, Holger; Kovacs, Peter; Krohn, Knut; Kronberg, Jaanika; Kukushkina, Viktorija; Kutalik, Zoltan; Lee, Bernett; Lehtimäki, Terho; Loeffler, Marku; Marigorta, Urko M.; Mei, Hailang; Milani, Lili; Montgomery, Grant W.; Müller-Nurasyid, Martina; Nauck, Matthia; Nivard, Michel G.; Penninx, Brenda W. J. H.; Perola, Marku; Pervjakova, Natalia; Pierce, Brandon L.; Powell, Joseph; Prokisch, Holger; Psaty, Bruce M.; Raitakari, Olli T.; Ripatti, Samuli; Rotzschke, Olaf; Rüeger, Sina; Saha, Ashi; Scholz, Marku; Schramm, Katharina; Seppälä, Ilkka; Slagboom, Eline P.; Stehouwer, Coen D. A.; Stumvoll, Michael; Sullivan, Patrick; ‘t Hoen, Peter A. C.; Teumer, Alexander; Thiery, Joachim; Tong, Lin; Tönjes, Anke; van Dongen, Jenny; van Iterson, Maarten; van Meurs, Joyce; Veldink, Jan H.; Verlouw, Joost; Visscher, Peter M.; Völker, Uwe; Võsa, Urmo; Westra, Harm-Jan; Wijmenga, Cisca; Yaghootkar, Hanieh; Yang, Jian; Zeng, Biao; Zhang, Futao; Isaacs, Aaron; Pool, René; Jan Hottenga, Jouke; van Greevenbroek, Marleen M. J.; van der Kallen, Carla J. H.; Schalkwijk, Casper G.
Publication Year: 2021
Collection: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
Subject Terms: genetics
Description: Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.
Document Type: article in journal/newspaper
File Description: ELETTRONICO
Language: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/34211149; info:eu-repo/semantics/altIdentifier/wos/WOS:000668823900002; volume:5; issue:12 (December); firstpage:1717; lastpage:1730; numberofpages:14; journal:NATURE HUMAN BEHAVIOUR; https://hdl.handle.net/11585/848362
DOI: 10.1038/s41562-021-01135-3
Availability: https://hdl.handle.net/11585/848362; https://doi.org/10.1038/s41562-021-01135-3
Rights: info:eu-repo/semantics/openAccess
Accession Number: edsbas.DB72D81D
Database: BASE