| Title: |
MRI-Based Assessment of Risk for Stroke in Moyamoya Angiopathy (MARS-MMA): An MRI-Based Scoring System for the Severity of Moyamoya Angiopathy |
| Authors: |
Zerweck, Leonie; Roder, Constantin; Blazhenets, Ganna; Martus, Peter; Thurow, Johannes; Haas, Patrick; Estler, Arne; Gohla, Georg; Ruff, Christer; Selo, Nadja; Würtemberger, Urs; Khan, Nadia; Klose, Uwe; Ernemann, Ulrike; Meyer, Philipp T; Hauser, Till-Karsten |
| Source: |
Zerweck, Leonie; Roder, Constantin; Blazhenets, Ganna; Martus, Peter; Thurow, Johannes; Haas, Patrick; Estler, Arne; Gohla, Georg; Ruff, Christer; Selo, Nadja; Würtemberger, Urs; Khan, Nadia; Klose, Uwe; Ernemann, Ulrike; Meyer, Philipp T; Hauser, Till-Karsten (2024). MRI-Based Assessment of Risk for Stroke in Moyamoya Angiopathy (MARS-MMA): An MRI-Based Scoring System for the Severity of Moyamoya Angiopathy. Diagnostics, 14(13):1437. |
| Publisher Information: |
MDPI Publishing |
| Publication Year: |
2024 |
| Collection: |
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| Subject Terms: |
Clinic for Surgery; 610 Medicine & health |
| Description: |
Before revascularization, moyamoya patients require hemodynamic evaluation. In this study, we evaluated the scoring system Prior Infarcts, Reactivity and Angiography in Moyamoya Disease (PIRAMID). We also devised a new scoring system, MRI-Based Assessment of Risk for Stroke in Moyamoya Angiopathy (MARS-MMA), and compared the scoring systems with respect to the capability to predict impaired [$^{15}$O]water PET cerebral perfusion reserve capacity (CPR). We evaluated 69 MRI, 69 DSA and 38 [$^{15}$O]water PET data sets. The PIRAMID system was validated by ROC curve analysis with neurological symptomatology as a dependent variable. The components of the MARS-MMA system and their weightings were determined by binary logistic regression analysis. The comparison of PIRAMID and MARS-MMA was performed by ROC curve analysis. The PIRAMID score correlated well with the symptomatology (AUC = 0.784). The MARS-MMA system, including impaired breath-hold-fMRI, the presence of the Ivy sign and arterial wall contrast enhancement, correlated slightly better with CPR impairment than the PIRAMID system (AUC = 0.859 vs. 0.827, Akaike information criterion 140 vs. 146). For simplified clinical use, we determined three MARS-MMA grades without loss of diagnostic performance (AUC = 0.855). The entirely MRI-based MARS-MMA scoring system might be a promising tool to predict the risk of stroke. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2075-4418 |
| Relation: |
https://www.zora.uzh.ch/id/eprint/275286/1/ZORA275286.pdf; info:pmid/39001327; urn:issn:2075-4418 |
| DOI: |
10.3390/diagnostics14131437 |
| Availability: |
https://www.zora.uzh.ch/id/eprint/275286/; https://www.zora.uzh.ch/id/eprint/275286/1/ZORA275286.pdf; https://doi.org/10.3390/diagnostics14131437 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.DB8D11CB |
| Database: |
BASE |