| Title: |
Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth |
| Authors: |
Di Candia, Francesca; Rosanio, Francesco Maria; Franceschi, Roberto; Fierro, Alessandro; Bonfanti, Riccardo; Cardella, Francesca; Cherubini, Valentino; D'Annunzio, Giuseppe; Felappi, Barbara; Iafusco, Dario; Iovane, Brunella; Maffeis, Claudio; Maltoni, Giulio; Olivieri, Francesca; Olivieri, Gabriele; Piccini, Barbara; Piccinno, Elvira; Predieri, Barbara; Rabbone, Ivana; Ricciardi, Maria Rossella; Salzano, Giuseppina; Schiaffini, Riccardo; Tornese, Gianluca; Zanfardino, Angela; Marigliano, Marco; Troncone, Riccardo; Pertile, Riccardo; Greco, Luigi; Auricchio, Renata; Mozzillo, Enza; null, null; Gallo, Francesco; Grosso, Caterina; Ripoli, Carlo; De Berardinis, Fiorella; Coccoli, Susanna; Tiberi, Valentina; Toni, Sonia; Delvecchio, Maurizio; Roppolo, Rosanna; Lombardo, Fortunato; Passanisi, Stefano; Bombaci, Bruno; Casertano, Alberto; Minuto, Nicola; Bassi, Marta; Maines, Evelina; Savastio, Silvia; Inzaghi, Elena; Rigamonti, Andrea; Frontino, Giulio; Bruzzi, Patrizia; Piona, Claudia |
| Contributors: |
Di Candia, Francesca; Rosanio, Francesco Maria; Franceschi, Roberto; Fierro, Alessandro; Bonfanti, Riccardo; Cardella, Francesca; Cherubini, Valentino; D'Annunzio, Giuseppe; Felappi, Barbara; Iafusco, Dario; Iovane, Brunella; Maffeis, Claudio; Maltoni, Giulio; Olivieri, Francesca; Olivieri, Gabriele; Piccini, Barbara; Piccinno, Elvira; Predieri, Barbara; Rabbone, Ivana; Ricciardi, Maria Rossella; Salzano, Giuseppina; Schiaffini, Riccardo; Tornese, Gianluca; Zanfardino, Angela; Marigliano, Marco; Troncone, Riccardo; Pertile, Riccardo; Greco, Luigi; Auricchio, Renata; Mozzillo, Enza; Null, Null; Gallo, Francesco; Grosso, Caterina; Ripoli, Carlo; De Berardinis, Fiorella; Coccoli, Susanna; Tiberi, Valentina; Toni, Sonia; Delvecchio, Maurizio; Roppolo, Rosanna; Lombardo, Fortunato; Passanisi, Stefano; Bombaci, Bruno; Casertano, Alberto; Minuto, Nicola; Bassi, Marta; Maines, Evelina; Savastio, Silvia; Inzaghi, Elena; Rigamonti, Andrea; Frontino, Giulio; Bruzzi, Patrizia; Piona, Claudia |
| Publication Year: |
2025 |
| Collection: |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| Subject Terms: |
Anti-tissue Transglutaminase; Autoimmunity; Celiac Disease; Gluten-Free Diet; Glycosylated haemoglobin; Type 1 Diabetes |
| Description: |
Context: Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in Coeliac Disease (CD). Objective: The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in children and adolescents with type 1 diabetes (T1D) at the time of CD diagnosis. As secondary outcomes, we assessed the optimal anti-TTG IgA upper limit of normal (ULN) cut-off for sparing biopsy, and personal and familial autoimmunity history in the individuals with T1D and CD (T1D-CD) compared with T1D-only. Design, setting, and patients retrospective observational study: Among 6933 individuals with T1D onset (2010-2019), 556 were grouped according to CD onset: before (CD_FIRST), concomitant (CD_CONCOMITANT), or after T1D (T1D_FIRST), and compared with 141 T1D without CD. Main outcome measures: HbA1cCD, Fold anti-TTG IgA, anti-TTG IgA cut-off, and autoimmunity history of both groups; Marsh grade, in T1D-CD. Results: In youths with T1D, HbA1cCD was associated with increased Fold anti-TTG IgA (Spearman Corr. r=0.14, p=0.0047). The optimal anti-TTG IgA cut-off for sparing biopsy was 11 ULN. Autoimmunity was prevalent in T1D-CD individuals, who showed more comorbidities than controls (χ2 25.4, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41186271; info:eu-repo/semantics/altIdentifier/wos/WOS:001618302600001; firstpage:1; lastpage:8; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; https://hdl.handle.net/11380/1390488 |
| DOI: |
10.1210/clinem/dgaf604 |
| Availability: |
https://hdl.handle.net/11380/1390488; https://doi.org/10.1210/clinem/dgaf604 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:[IR] creative-commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.DBB05921 |
| Database: |
BASE |