A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
| Title: | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
|---|---|
| Authors: | Rothman N; Garcia Closas M; Chatterjee N; Malats N; Wu X; Figueroa JD; Real FX; Den Berg DV; Matullo G; Baris D; Thun M; Kiemeney L; Vineis P; Vivo ID; Albanes D; Purdue MP; Rafnar T; MA Hildebrandt; Kiltie AE; Cussenot O; Golka K; Kumar R; Taylor JA; Mayordomo JI; Jacobs KB; Kogevinas M; Hutchinson A; Wang Z; Fu Y; Prokunina Olsson L; Burdett L; Yeager M; Wheeler W; Tardón A; Serra C; Carrato A; García Closas R; Lloreta J; Johnson A; Schwenn M; Karagas MR; Schned A; Andriole G; Grubb R; Black A; Jacobs EJ; Diver WR; Gapstur SM; Weinstein SJ; Virtamo J; Cortessis VK; Gago Dominguez M; Pike MC; Stern MC; Yuan J; Hunter DJ; McGrath M; Dinney CP; Czerniak B; Chen M; Yang H; Vermeulen SH; Aben KK; Witjes JA; Makkinje RR; Sulem P; Besenbacher S; Stefansson K; Riboli E; Brennan P; Panico S; Navarro C; Allen NE; Bueno de Mesquita HB; Trichopoulos D; Caporaso N; Landi MT; Canzian F; Ljungberg B; Tjonneland A; Clavel Chapelon F; Bishop DT; Teo MT; Knowles MA; Guarrera S; Polidoro S; Ricceri F; Sacerdote C; Allione A; Cancel Tassin G; Selinski S; Hengstler JG; Dietrich H; Fletcher T; Rudnai P; Gurzau E; Koppova K; Bolick SC; Godfrey A; Xu Z; Sanz Velez JI; García Prats MD; Sanchez M; Valdivia G; Benhamou S; Hoover RN; Fraumeni JF; Silverman DT; Chanock SJ; PORRU, Stefano |
| Contributors: | Rothman, N; Garcia Closas, M; Chatterjee, N; Malats, N; Wu, X; Figueroa, Jd; Real, Fx; Den Berg, Dv; Matullo, G; Baris, D; Thun, M; Kiemeney, L; Vineis, P; Vivo, Id; Albanes, D; Purdue, Mp; Rafnar, T; Ma, Hildebrandt; Kiltie, Ae; Cussenot, O; Golka, K; Kumar, R; Taylor, Ja; Mayordomo, Ji; Jacobs, Kb; Kogevinas, M; Hutchinson, A; Wang, Z; Fu, Y; Prokunina Olsson, L; Burdett, L; Yeager, M; Wheeler, W; Tardón, A; Serra, C; Carrato, A; García Closas, R; Lloreta, J; Johnson, A; Schwenn, M; Karagas, Mr; Schned, A; Andriole, G; Grubb, R; Black, A; Jacobs, Ej; Diver, Wr; Gapstur, Sm; Weinstein, Sj; Virtamo, J; Cortessis, Vk; Gago Dominguez, M; Pike, Mc; Stern, Mc; Yuan, J; Hunter, Dj; Mcgrath, M; Dinney, Cp; Czerniak, B; Chen, M; Yang, H; Vermeulen, Sh; Aben, Kk; Witjes, Ja; Makkinje, Rr; Sulem, P; Besenbacher, S; Stefansson, K; Riboli, E; Brennan, P; Panico, S; Navarro, C; Allen, Ne; Bueno de Mesquita, Hb; Trichopoulos, D; Caporaso, N; Landi, Mt; Canzian, F; Ljungberg, B; Tjonneland, A; Clavel Chapelon, F; Bishop, Dt; Teo, Mt; Knowles, Ma; Guarrera, S; Polidoro, S; Ricceri, F; Sacerdote, C; Allione, A; Cancel Tassin, G; Selinski, S; Hengstler, Jg; Dietrich, H; Fletcher, T; Rudnai, P; Gurzau, E; Koppova, K; Bolick, Sc; Godfrey, A; Xu, Z |
| Publication Year: | 2010 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Description: | We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10−12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10−11) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10−7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10−11) and a tag SNP for NAT2 acetylation status (P = 4 × 10−11), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/20972438; info:eu-repo/semantics/altIdentifier/wos/WOS:000283540500015; volume:42(11); firstpage:978; lastpage:984; numberofpages:7; journal:NATURE GENETICS; https://hdl.handle.net/11562/956135 |
| DOI: | 10.1038/ng.687 |
| Availability: | https://hdl.handle.net/11562/956135; https://doi.org/10.1038/ng.687 |
| Accession Number: | edsbas.DBC93C5 |
| Database: | BASE |