| Title: |
Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
| Authors: |
Cattaneo, Chiara; Salmanton-García, Jon; Marchesi, F.; El-Ashwah, Shaimaa; Itri, Federico; Weinbergerová, Barbora; Gomes da Silva, Maria; Dargenio, Michelina; Dávila-Valls, Julio; Martín-Pérez, Sonia; Farina, Francesca; van Doesum, Jaap A.; Valković, Toni; Besson, Caroline M.; Poulsen, Christian Bjørn; López-García, Alberto; Žák, Pavel; Schönlein, Martin; Piukovics, Klára; Jaksic, Ozren; Cabirta, Alba; Ali, Natasha Bahadur; Sili, Uluhan; Fracchiolla, Nicola Stefano; Dragonetti, Giulia; Adžić-Vukičević, Tatjana N.; Marchetti, Monia; Machado, Marina; Glenthøj, Andreas Birkedal; Finizio, Olimpia; Demirkan, Fatih; Blennow, Ola; Tisi, Maria Chiara; Omrani, Ali S.; Navrátil, Milan; Ráčil, Zdeněk; Novák, Jan; Magliano, Gabriele; Jiménez, Moraima; Garcia-Vidal, Carolina; Erben, N.; del Principe, Maria Ilaria; Buquicchio, Caterina; Bergantim, Rui; Batinić, Josip; Al-Khabori, Murtadha K.; Verga, Luisa; Szotkowski, Tomáš; Samarkos, Michael; Ormazabal-Vélez, Irati; Meers, Stef; Maertens, Johan A.; Pinczés, László Imre; Hoenigl, Martin; Drgoňa, L’uboš; Cuccaro, Annarosa; Bilgin, Yavuz M.; Aujayeb, Avinash; Rahimli, Laman; Gräfe, Stefanie K.; Sciumè, Mariarita; Mladenović, Miloš; Çolak, Gökçe Melis; Sacchi, Maria Vittoria; Nordlander, Anna; Berg Venemyr, Caroline; Hanáková, Michaela; García-Poutón, Nicole; Emarah, Ziad A.; Zambrotta, Giovanni Paolo Maria; Nunes Rodrigues, Raquel; Cordoba, Raúl; Méndez, Gustavo Adolfo; Biernat, Monika Maria; Cornely, Oliver A.; Pagano, Livio |
| Contributors: |
Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; EPICOVIDEHA has received funds from Optics COMMITTM (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223). |
| Source: |
ISSN: 2072-6694. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2022 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
treatment; prognostic factors; outcome; haematological malignancy onset; COVID-19; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, ≥2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36428621; PUBMED: 36428621 |
| DOI: |
10.3390/cancers14225530 |
| Availability: |
https://hal.science/hal-03888943; https://hal.science/hal-03888943v1/document; https://hal.science/hal-03888943v1/file/cancers-14-05530-v2.pdf; https://doi.org/10.3390/cancers14225530 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.DBD491A1 |
| Database: |
BASE |