| Title: |
Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia |
| Authors: |
Sánchez van Kammen, Mayte; Aguiar de Sousa, Diana; Poli, Sven; Cordonnier, Charlotte; Heldner, Mirjam; van de Munckhof, Anita; Krzywicka, Katarzyna; van Haaps, Thijs; Ciccone, Alfonso; Middeldorp, Saskia; Levi, Marcel; Kremer Hovinga, Johanna; Silvis, Suzanne; Hiltunen, Sini; Mansour, Maryam; Arauz, Antonio; Barboza, Miguel; Field, Thalia; Tsivgoulis, Georgios; Nagel, Simon; Lindgren, Erik; Tatlisumak, Turgut; Jood, Katarina; Putaala, Jukka; Ferro, Jose; Arnold, Marcel; Coutinho, Jonathan; Sharma, Aarti; Elkady, Ahmed; Negro, Alberto; Günther, Albrecht; Gutschalk, Alexander; Schönenberger, Silvia; Buture, Alina; Murphy, Sean; Paiva Nunes, Ana; Tiede, Andreas; Puthuppallil Philip, Anemon; Mengel, Annerose; Medina, Antonio; Hellström Vogel, Åslög; Tawa, Audrey; Aujayeb, Avinash; Casolla, Barbara; Buck, Brian; Zanferrari, Carla; Garcia-Esperon, Carlos; Vayne, Caroline; Legault, Catherine; Pfrepper, Christian; Tracol, Clement; Soriano, Cristina; Guisado-Alonso, Daniel; Bougon, David; Zimatore, Domenico; Michalski, Dominik; Blacquiere, Dylan; Johansson, Elias; Cuadrado-Godia, Elisa; de Maistre, Emmanuel; Carrera, Emmanuel; Vuillier, Fabrice; Bonneville, Fabrice; Giammello, Fabrizio; Bode, Felix; Zimmerman, Julian; D’onofrio, Florindo; Grillo, Francesco; Cotton, Francois; Caparros, François; Puy, Laurent; Maier, Frank; Gulli, Giosue; Frisullo, Giovanni; Polkinghorne, Gregory; Franchineau, Guillaume; Cangür, Hakan; Katzberg, Hans; Sibon, Igor; Baharoglu, Irem; Brar, Jaskiran; Payen, Jean-François; Burrow, Jim; Fernandes, João; Schouten, Judith; Althaus, Katharina; Garambois, Katia; Derex, Laurent; Humbertjean, Lisa; Lebrato Hernandez, Lucia; Kellermair, Lukas; Morin Martin, Mar; Petruzzellis, Marco; Cotelli, Maria; Dubois, Marie-Cécile; Carvalho, Marta; Wittstock, Matthias; Miranda, Miguel; Skjelland, Mona; Bandettini Di Poggio, Monica; Scholz, Moritz; Raposo, Nicolas; Kahnis, Robert; Kruyt, Nyika; Huet, Olivier; Sharma, Pankaj; Candelaresi, Paolo; Reiner, Peggy; Vieira, Ricardo; Acampora, Roberto; Kern, Rolf; Leker, Ronen; Coutts, Shelagh; Bal, Simerpreet; Sharma, Shyam; Susen, Sophie; Cox, Thomas; Geeraerts, Thomas; Gattringer, Thomas; Bartsch, Thorsten; Kleinig, Timothy; Dizonno, Vanessa; Arslan, Yıldız |
| Contributors: |
Amsterdam University Medical Centers (Amsterdam UMC); Universidade de Lisboa = University of Lisbon = Université de Lisbonne Lisboa (ULISBOA); Eberhard Karls Universität Tübingen = University of Tübingen; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Bern University Hospital Berne (Inselspital); Azienda Socio Sanitaria Territoriale di Mantova Mantova, Italy (ASST); Radboud University Medical Center Nijmegen (RadboudUMC); University College London Hospitals (UCLH); Helsinki University Hospital Finland (HUS); Service Neuroradiologie Diagnostique et Thérapeutique CHU Toulouse; Pôle imagerie médicale CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Toulouse NeuroImaging Center (ToNIC); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI); Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Département Neurologie CHU Toulouse; Pôle Neurosciences CHU Toulouse; Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST); Optimisation des régulations physiologiques (ORPHY (EA 4324)); Université de Brest (UBO EPE)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM); Université de Brest (UBO EPE)-Université de Brest (UBO EPE); Pôle Anesthésie Réanimation CHU de Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); ANR-10-IAHU-0002,IHU de Strasbourg (ex MIX-Surg),Institut de Chirurgie Mini-Invasive guidée par l'Image(2010) |
| Source: |
ISSN: 2168-6149. |
| Publisher Information: |
CCSD; American Medical Association |
| Publication Year: |
2021 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Ad26COVS1; MESH: Adult; MESH: Hospital Mortality; MESH: Humans; MESH: Male; MESH: Middle Aged; MESH: Outcome Assessment; Health Care; MESH: Registries; MESH: Sex Factors; MESH: Sinus Thrombosis; Intracranial / blood; MESH: Aged; MESH: BNT162 Vaccine; MESH: COVID-19 Vaccines / adverse effects; MESH: COVID-19 Vaccines / therapeutic use; MESH: ChAdOx1 nCoV-19; MESH: Cohort Studies; MESH: Drug-Related Side Effects and Adverse Reactions / mortality; MESH: Female; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Importance: Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson).Objective: To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS.Design, setting, and participants: This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 were derived from an existing international registry. Clinical characteristics and mortality rate were described for adults with (1) CVST in the setting of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia, (2) CVST after SARS-CoV-2 vaccination not fulling criteria for TTS, and (3) CVST unrelated to SARS-CoV-2 vaccination.Exposures: Patients were classified as having TTS if they had new-onset thrombocytopenia without recent exposure to heparin, in accordance with the Brighton Collaboration interim criteria.Main outcomes and measures: Clinical characteristics and mortality rate.Results: Of 116 patients with postvaccination CVST, 78 (67.2%) had TTS, of whom 76 had been vaccinated with ChAdOx1 nCov-19; 38 (32.8%) had no indication of TTS. The control group included 207 patients with CVST before the COVID-19 pandemic. A total of 63 of 78 (81%), 30 of 38 (79%), and 145 of 207 (70.0%) patients, respectively, were female, and the mean (SD) age was 45 (14), 55 (20), and 42 (16) years, respectively. Concomitant thromboembolism occurred in 25 of 70 patients (36%) in the TTS group, 2 of 35 (6%) in the no TTS group, and 10 of 206 (4.9%) in the control group, and in-hospital mortality rates were 47% (36 of 76; 95% CI, 37-58), 5% (2 of 37; 95% CI, 1-18), and 3.9% (8 of 207; 95% CI, 2.0-7.4), respectively. ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34581763; PUBMED: 34581763; PUBMEDCENTRAL: PMC8479648 |
| DOI: |
10.1001/jamaneurol.2021.3619 |
| Availability: |
https://hal.science/hal-04074963; https://doi.org/10.1001/jamaneurol.2021.3619 |
| Accession Number: |
edsbas.DBE6E475 |
| Database: |
BASE |