| Title: |
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium |
| Authors: |
Lophatananon, A; Stewart-Brown, S; Kote-Jarai, Z; Olama, AAA; Garcia, SB; Neal, DE; Hamdy, FC; Donovan, JL; Giles, GG; Fitzgerald, LM; Southey, MC; Pharoah, P; Pashayan, N; Gronberg, H; Wiklund, F; Aly, M; Stanford, JL; Brenner, H; Dieffenbach, AK; Arndt, V; Park, JY; Lin, H-Y; Sellers, T; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Spurdle, A; Clements, JA; APCB BioResource, .; PRACTICAL consortium, .; Easton, D; Eeles, RA; Muir, K |
| Source: |
British Journal of Cancer (2017) |
| Publication Year: |
2017 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Height; SNPs; gene and environment interaction; prostate cancer |
| Description: |
BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1570453/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1570453/1/Lophatananon%20et%20al%20-2017%20-%20Height%20and%20Pca%20-BJC.pdf; https://discovery.ucl.ac.uk/id/eprint/1570453/ |
| Rights: |
open |
| Accession Number: |
edsbas.DBE95EE |
| Database: |
BASE |