| Title: |
Rare variation in drug metabolism and Long QT genes and the genetic susceptibility to acquired Long QT syndrome |
| Authors: |
Gray, B; Baruteau, AE; Antolin, AA; Pittman, A; Sarganas, G; Molokhia, M; Blom, MT; Bastiaenen, R; Bardai, A; Priori, SG; Napolitano, C; Weeke, PE; Shakir, SA; Haverkamp, W; Mestres, J; Winkel, B; Witney, AA; Chis-Ster, I; Sangaralingam, A; Camm, AJ; Tfelt-Hansen, J; Roden, DM; Tan, HL; Garbe, E; Sturkenboom, MCJM; Behr, ER |
| Publisher Information: |
Zenodo |
| Publication Year: |
2022 |
| Collection: |
Zenodo |
| Description: |
Background: Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk. Methods: Among 153 aLQTS patients (mean age 58 years [range, 14–88], 98.7% White, 85.6% symptomatic), computational methods identified proteins interacting most significantly with 216 QT-prolonging drugs. All cases underwent sequencing of 31 candidate genes arising from this analysis or associating with congenital LQTS. Variants were filtered using a minor allele frequency |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://zenodo.org/communities/escape-net/; https://zenodo.org/communities/eu/; https://zenodo.org/records/5899144; oai:zenodo.org:5899144; https://doi.org/10.1161/CIRCGEN.121.003391 |
| DOI: |
10.1161/CIRCGEN.121.003391 |
| Availability: |
https://doi.org/10.1161/CIRCGEN.121.003391; https://zenodo.org/records/5899144 |
| Rights: |
Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode |
| Accession Number: |
edsbas.DC04EB0E |
| Database: |
BASE |