| Title: |
STING activation by teniposide: a potential direct mechanism beyond cGAS stimulation |
| Authors: |
Arranz-Herrero, Javier; Marquez-Cantudo, Laura; Rius-Rocabert, Sergio; Buey, Rubén M.; Velazquez-Campoy, Adrian; Tur-Planells, Vicent; Garcia-Sastre, Adolfo; Miorin, Lisa; de Pascual-Teresa, Beatriz; Coderch, Claire; Nistal-Villan, Estanislao |
| Contributors: |
European Commission; Ministerio de Ciencia e Innovación (España); Universidad de San Pablo-CEU; Banco Santander; Comunidad de Madrid; Buey, Rubén M. |
| Publisher Information: |
Frontiers Media |
| Publication Year: |
2026 |
| Collection: |
Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| Subject Terms: |
Cyclic dinucleotides (CDNs); High-throughput virtual screening (HTVS); IFN-β; Immunotherapy drug repurposing; Isothermal titration calorimetry (ITC); Molecular docking; STING; Teniposide |
| Description: |
14 páginas, 4 figuras ; The STimulator of Interferon Genes (STING) is a key adaptor protein in the innate immune response to cytosolic DNA, making it a promising therapeutic target. Identifying novel STING ligands could provide new opportunities for immune modulation. ; The author(s) declared that financial support was received for this work and/or its publication. This work was supported by FEDER/FSE and ISCIII, which co-founded the PFIS fellowship of JA-H. CC and BP-T acknowledge financial support by MICINN through the PID2021-123786OB-I00 project. LM acknowledges Universidad San Pablo CEU and Banco Santander for funding through a Young Researcher contract. VT-P acknowledges PIPF Fellowship funded by Comunidad de Madrid, PIPF-2023/SAL-GL- 30638. RB acknowledges funding from MICINN projects PID2019-109671GB-I00 and PID2023-146797OB-C33. EN-V acknowledges this work was possible thanks to MICINN project PID2023-150116OB-I00. This work was also partially supported by the NIAID adjuvant program, contract # 75N93019C00046, to AG-S ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
#PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123786OB-I00/ES/DESARROLLO DE DEGRADADORES DE PROTEINAS (PROTACS Y LYTACS) DIRIGIDOS A CELULAS TUMORALES. MARCADORES PET Y FLUORESCENTES PARA ENZIMAS IMPLICADAS EN CANCER Y OSTEOARTRITIS./; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109671GB-I00/ES/IMP DESHIDROGENASA: ESTRUCTURA, FUNCION E IDENTIFICACION DE COMPUESTOS MODULADORES/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-146797OB-C33/ES/AVANZANDO EN VACUNAS SEGURAS CONTRA LA BRUCELOSIS OVINA: EFICACIA DE CANDIDATOS VACUNALES MEJORADOS DE B. MELITENSIS Y B. OVIS Y MODELOS IN VITRO INNOVADORES/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-150116OB-I00/ES/ANALISIS DE LA INTERACCION HOSPEDADOR-PATOGENOS EN EL MARCO DEL VIRUS INFLUENZA Y SUPERINFECCION BACTERIANA/; http://dx.doi.org/10.3389/fimmu.2025.1677836; Sí; Frontiers in Immunology 16: 1677836 (2026); https://hdl.handle.net/10261/421087; https://api.elsevier.com/content/abstract/scopus_id/105027687593 |
| DOI: |
10.3389/fimmu.2025.1677836 |
| Availability: |
https://hdl.handle.net/10261/421087; https://doi.org/10.3389/fimmu.2025.1677836; https://api.elsevier.com/content/abstract/scopus_id/105027687593 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.DC28D566 |
| Database: |
BASE |