| Title: |
DoxyPEP for cisgender women and people assigned female at birth |
| Authors: |
Irons, Rebecca; Stewart, Jenell; Harding-Esch, Emma; Greiner, Rosamund; Savanhu, Juliet |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2026 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Responding to the continued rise of bacterial sexually transmitted infections (STIs), in June 2025, the British Association for Sexual Health and HIV (BASHH) published a UK-first guideline on the use of doxycycline as post-exposure prophylaxis (DoxyPEP) for syphilis and chlamydia prevention.1 However, in the new guidelines, DoxyPEP is not recommended for cisgender women and people who were assigned female at birth, regardless of gender. In August 2025, an expert roundtable was held at University College London (London, UK) to discuss the next steps for STI prevention for this group, from a clinical, ethical, and policy perspective. In response to an earlier published Correspondence in The Lancet Infectious Diseases,2 we suggest that although guidelines cannot explicitly recommend DoxyPEP for all cisgender women and people who were assigned female at birth due to scarce efficacy data, clinician guidance on when and how to recommend DoxyPEP should be clarified to better raise awareness and address unmet need for this group. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
3050-5038 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4680641/1/Irons-etal-2026-DoxyPEP-for-Cisgender-women-and-people-assigned-female-at-birth.pdf; Irons, Rebecca; Stewart, Jenell; Harding-Esch, Emma ORCID logo; Greiner, Rosamund; and Savanhu, Juliet (2026) DoxyPEP for cisgender women and people assigned female at birth. The Lancet Obstetrics, Gynaecology, & Women's Health, 2 (2). e88-e89. ISSN 3050-5038 DOI:10.1016/s3050-5038(25)00208-0 |
| DOI: |
10.1016/s3050-5038(25)00208-0 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4680641/; https://doi.org/10.1016/s3050-5038(25)00208-0 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.DC7BAD45 |
| Database: |
BASE |