| Title: |
paraCell: A novel software tool for the interactive analysis and visualization of standard and dual host-parasite single cell RNA-Seq data |
| Authors: |
Agboraw, Edward; Haese-Hill, William; Hentzschel, Franziska; Marie Briggs, Emma; Aghabi, Dana; Heawood, Anna; Harding, Clare R.; Shiels, Brian; Crouch, Kathryn R.; Somma, Domenico; Otto, Thomas D. |
| Publication Year: |
2024 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
Advances in sequencing technology have led to a dramatic increase in the number of single-cell transcriptomic datasets available. In the field of parasitology these datasets typically describe the gene expression patterns of a given parasite species under specific experimental conditions, in specific hosts or tissues, or at different life-cycle stages. However, while this wealth of available data represents a significant resource for further research, the analysis of these datasets often requires significant computational skills, preventing a considerable proportion of the parasitology community from meaningfully incorporating existing single-cell data into their work. Here, we present paraCell, a novel software tool that automates the advanced analysis of published single-cell data without requiring any programming ability. On our free web-server, we demonstrated how to visualise data, re-analyse published Plasmodium and Trypanosoma datasets, and present novel Toxoplasma-mouse and Theileira-cow atlases to study the impact of IFN-γ and host genetic susceptibility. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/345968/1/345968.pdf; Agboraw, E. et al. (2024) paraCell: A novel software tool for the interactive analysis and visualization of standard and dual host-parasite single cell RNA-Seq data. bioRxiv , (doi:10.1101/2024.08.29.610375 ) |
| DOI: |
10.1101/2024.08.29.610375 |
| Availability: |
https://eprints.gla.ac.uk/345968/; https://eprints.gla.ac.uk/345968/1/345968.pdf; https://doi.org/10.1101/2024.08.29.610375 |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.DCA6ABBD |
| Database: |
BASE |