| Title: |
Compensatory Vascular Remodeling During Atherosclerotic Lesion Growth Depends on Matrix Metalloproteinase-9 Activity |
| Authors: |
Lessner, Susan M.; Martinson, Deborah E.; Galis, Zorina S. |
| Source: |
Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 24, issue 11, page 2123-2129 ; ISSN 1079-5642 1524-4636 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2004 |
| Description: |
Objective— The compensatory arterial remodeling associated with atherosclerotic plaques is thought to rely on the activity of matrix metalloproteinases (MMP). To assess the role of MMP-9, we analyzed the effect of MMP-9 genetic deficiency on the development and remodeling of experimental atherosclerotic lesions induced in the apolipoprotein E (apoE) knockout (−/−) mouse model. Methods and Results— We analyzed remodeling parameters and cellular composition of experimental carotid artery atherosclerotic lesions in apoE−/− and apoE−/− MMP-9−/− double-knockout (DKO) mice at 0, 3, 7, and 14 days after induction by flow cessation. Morphometric image analysis of arterial tissue sections indicated that overall artery size, measured as area encompassed by the external elastic lamina, increased 3.1-fold in the apoE−/− mice but only 1.6-fold in the DKO mice ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.atv.0000141840.27300.fd |
| DOI: |
10.1161/01.ATV.0000141840.27300.fd |
| Availability: |
https://doi.org/10.1161/01.atv.0000141840.27300.fd; https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000141840.27300.fd |
| Accession Number: |
edsbas.DCF8C3EF |
| Database: |
BASE |