Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
| Title: | Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study |
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| Authors: | Ou A. H.; Rosenthal S. B.; Adli M.; Akiyama K.; Akula N.; Alda M.; Amare A. T.; Ardau R.; Arias B.; Aubry J. -M.; Backlund L.; Bauer M.; Baune B. T.; Bellivier F.; Benabarre A.; Bengesser S.; Bhattacharjee A. K.; Biernacka J. M.; Cervantes P.; Chen G. -B.; Chen H. -C.; Chillotti C.; Cichon S.; Clark S. R.; Colom F.; Cousins D. A.; Cruceanu C.; Czerski P. M.; Dantas C. R.; Dayer A.; Del Zompo M.; Degenhardt F.; DePaulo J. R.; Etain B.; Falkai P.; Fellendorf F. T.; Ferensztajn-Rochowiak E.; Forstner A. J.; Frisen L.; Frye M. A.; Fullerton J. M.; Gard S.; Garnham J. S.; Goes F. S.; Grigoroiu-Serbanescu M.; Grof P.; Gruber O.; Hashimoto R.; Hauser J.; Heilbronner U.; Herms S.; Hoffmann P.; Hofmann A.; Hou L.; Jamain S.; Jimenez E.; Kahn J. -P.; Kassem L.; Kato T.; Kittel-Schneider S.; Konig B.; Kuo P. -H.; Kusumi I.; Lackner N.; Laje G.; Landen M.; Lavebratt C.; Leboyer M.; Leckband S. G.; Jaramillo C. A. L.; MacQueen G.; Maj M.; Manchia M.; Marie-Claire C.; Martinsson L.; Mattheisen M.; McCarthy M. J.; McElroy S. L.; McMahon F. J.; Mitchell P. B.; Mitjans M.; Mondimore F. M.; Monteleone P.; Nievergelt C. M.; Nothen M. M.; Novak T.; Osby U.; Ozaki N.; Papiol S.; Perlis R. H.; Pisanu C.; Potash J. B.; Pfennig A.; Reich-Erkelenz D.; Reif A.; Reininghaus E. Z.; Rietschel M.; Rouleau G. A.; Rybakowski J. K.; Schalling M.; Schofield P. R.; Schubert K. O.; Schulze T. G.; Schweizer B. W.; Seemuller F.; Severino G.; Shekhtman T.; Shilling P. D.; Shimoda K.; Simhandl C.; Slaney C. M.; Squassina A.; Stamm T.; Stopkova P.; Tighe S. K.; Tortorella A.; Turecki G.; Vieta E.; Volkert J.; Witt S.; Wray N. R.; Wright A.; Young L. T.; Zandi P. P.; Kelsoe J. R. |
| Contributors: | Ou, A. H.; Rosenthal, S. B.; Adli, M.; Akiyama, K.; Akula, N.; Alda, M.; Amare, A. T.; Ardau, R.; Arias, B.; Aubry, J. -M.; Backlund, L.; Bauer, M.; Baune, B. T.; Bellivier, F.; Benabarre, A.; Bengesser, S.; Bhattacharjee, A. K.; Biernacka, J. M.; Cervantes, P.; Chen, G. -B.; Chen, H. -C.; Chillotti, C.; Cichon, S.; Clark, S. R.; Colom, F.; Cousins, D. A.; Cruceanu, C.; Czerski, P. M.; Dantas, C. R.; Dayer, A.; Del Zompo, M.; Degenhardt, F.; Depaulo, J. R.; Etain, B.; Falkai, P.; Fellendorf, F. T.; Ferensztajn-Rochowiak, E.; Forstner, A. J.; Frisen, L.; Frye, M. A.; Fullerton, J. M.; Gard, S.; Garnham, J. S.; Goes, F. S.; Grigoroiu-Serbanescu, M.; Grof, P.; Gruber, O.; Hashimoto, R.; Hauser, J.; Heilbronner, U.; Herms, S.; Hoffmann, P.; Hofmann, A.; Hou, L.; Jamain, S.; Jimenez, E.; Kahn, J. -P.; Kassem, L.; Kato, T.; Kittel-Schneider, S.; Konig, B.; Kuo, P. -H.; Kusumi, I.; Lackner, N.; Laje, G.; Landen, M.; Lavebratt, C.; Leboyer, M.; Leckband, S. G.; Jaramillo, C. A. L.; Macqueen, G.; Maj, M.; Manchia, M.; Marie-Claire, C.; Martinsson, L.; Mattheisen, M.; Mccarthy, M. J.; Mcelroy, S. L.; Mcmahon, F. J.; Mitchell, P. B.; Mitjans, M.; Mondimore, F. M.; Monteleone, P.; Nievergelt, C. M.; Nothen, M. M.; Novak, T.; Osby, U.; Ozaki, N.; Papiol, S.; Perlis, R. H.; Pisanu, C.; Potash, J. B.; Pfennig, A.; Reich-Erkelenz, D.; Reif, A.; Reininghaus, E. Z.; Rietschel, M.; Rouleau, G. A.; Rybakowski, J. K.; Schalling, M. |
| Publication Year: | 2024 |
| Collection: | Università degli Studi di Cagliari: UNICA IRIS |
| Description: | Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38395906; info:eu-repo/semantics/altIdentifier/wos/WOS:001184990300003; volume:14; issue:1; journal:TRANSLATIONAL PSYCHIATRY; https://hdl.handle.net/11584/403103; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891068/ |
| DOI: | 10.1038/s41398-024-02811-4 |
| Availability: | https://hdl.handle.net/11584/403103; https://doi.org/10.1038/s41398-024-02811-4; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891068/ |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.DD2429D3 |
| Database: | BASE |