| Title: |
The Danish Nationwide osteoporosis cohort trials environment (NOCTE) – a DXA dataset for the 1900-1960 birth cohort |
| Authors: |
Hansen, Benjamin Bakke; Haddock, Bryan; Jørgensen, Niklas Rye; Vestergaard, Peter; Wiil, Uffe Kock; Folkestad, Lars; Möller, Sören; Fuggle, Nicholas; Langdahl, Bente; Rubin, Katrine Hass; Abrahamsen, Bo |
| Source: |
Hansen, B B, Haddock, B, Jørgensen, N R, Vestergaard, P, Wiil, U K, Folkestad, L, Möller, S, Fuggle, N, Langdahl, B, Rubin, K H & Abrahamsen, B 2026, 'The Danish Nationwide osteoporosis cohort trials environment (NOCTE) – a DXA dataset for the 1900-1960 birth cohort', Journal of Clinical Densitometry, vol. 29, no. 1, 101653. https://doi.org/10.1016/j.jocd.2025.101653 |
| Publication Year: |
2026 |
| Collection: |
Aarhus University: Research |
| Subject Terms: |
BMD; Cohort; DXA; Endocrinology; Epidemiology; Osteoporosis |
| Description: |
Background: Osteoporosis is a common, underdiagnosed condition causing increased risk of fracture. While dual-energy X-ray absorptiometry (DXA) is the diagnostic standard, this may not be successfully targeted to individuals at the highest risk. This study presents an extensive nationwide dataset characterizing DXA-scanning practices in Denmark. Methodology: In this study, we identified all Danish residents from the birth cohort 1900-1960, with a first DXA scan between 2010-2022 to form the Nationwide Osteoporosis Cohort Trials Environment (NOCTE) dataset. These individuals were matched 1:5 to a non-scanned reference population by birth year, sex, and region of residence. Individual data were linked to national registers for comprehensive sociodemographic and clinical information. Results: The final cohort included 263,651 individuals who underwent DXA scanning. At their first scan, 33% of women and 17% of men had osteoporosis. Compared to the matched reference, the scanned cohort had similar socioeconomic profiles but substantially different clinical profiles. Scanned individuals had a much higher prevalence of prior major osteoporotic fractures, prior systemic glucocorticoid exposure, and overall comorbidity burden. Conclusion: Referral for DXA in Denmark is driven by clinical risk rather than socioeconomic status, reflecting an equitable resource allocation. However, a significant diagnostic gap persists, as many high-risk individuals with prior fractures did not receive a DXA. The NOCTE cohort is a new, powerful resource for developing strategies to help close this gap. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1094-6950; 1559-0747 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41317664; info:eu-repo/semantics/altIdentifier/pissn/1094-6950; info:eu-repo/semantics/altIdentifier/eissn/1559-0747 |
| DOI: |
10.1016/j.jocd.2025.101653 |
| Availability: |
https://pure.au.dk/portal/en/publications/b1e44380-6695-4aca-baa5-c285523da43d; https://doi.org/10.1016/j.jocd.2025.101653; https://www.scopus.com/pages/publications/105023571200 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.DD55239D |
| Database: |
BASE |