| Title: |
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. |
| Authors: |
Docherty, A.R.; Mullins, N.; Ashley-Koch, A.E.; Qin, X.; Coleman, JRI; Shabalin, A.; Kang, J.; Murnyak, B.; Wendt, F.; Adams, M.; Campos, A.I.; DiBlasi, E.; Fullerton, J.M.; Kranzler, H.R.; Bakian, A.V.; Monson, E.T.; Rentería, M.E.; Walss-Bass, C.; Andreassen, O.A.; Behera, C.; Bulik, C.M.; Edenberg, H.J.; Kessler, R.C.; Mann, J.J.; Nurnberger, J.I.; Pistis, G.; Streit, F.; Ursano, R.J.; Polimanti, R.; Dennis, M.; Garrett, M.; Hair, L.; Harvey, P.; Hauser, E.R.; Hauser, M.A.; Huffman, J.; Jacobson, D.; Madduri, R.; McMahon, B.; Oslin, D.W.; Trafton, J.; Awasthi, S.; Berrettini, W.H.; Bohus, M.; Chang, X.; Chen, H.C.; Chen, W.J.; Christensen, E.D.; Crow, S.; Duriez, P.; Edwards, A.C.; Fernández-Aranda, F.; Galfalvy, H.; Gandal, M.; Gorwood, P.; Guo, Y.; Hafferty, J.D.; Hakonarson, H.; Halmi, K.A.; Hishimoto, A.; Jain, S.; Jamain, S.; Jiménez-Murcia, S.; Johnson, C.; Kaplan, A.S.; Kaye, W.H.; Keel, P.K.; Kennedy, J.L.; Kim, M.; Klump, K.L.; Levey, D.F.; Li, D.; Liao, S.C.; Lieb, K.; Lilenfeld, L.; Marshall, C.R.; Mitchell, J.E.; Okazaki, S.; Otsuka, I.; Pinto, D.; Powers, A.; Ramoz, N.; Ripke, S.; Roepke, S.; Rozanov, V.; Scherer, S.W.; Schmahl, C.; Sokolowski, M.; Starnawska, A.; Strober, M.; Su, M.H.; Thornton, L.M.; Treasure, J.; Ware, E.B.; Watson, H.J.; Witt, S.H.; Woodside, D.B.; Yilmaz, Z.; Zillich, L.; Adolfsson, R.; Agartz, I.; Alda, M.; Alfredsson, L.; Appadurai, V.; Artigas, M.S.; Van der Auwera, S.; Azevedo, M.H.; Bass, N.; Bau, CHD; Baune, B.T.; Bellivier, F.; Berger, K.; Biernacka, J.M.; Bigdeli, T.B.; Binder, E.B.; Boehnke, M.; Boks, M.P.; Braff, D.L.; Bryant, R.; Budde, M.; Byrne, E.M.; Cahn, W.; Castelao, E.; Cervilla, J.A.; Chaumette, B.; Corvin, A.; Craddock, N.; Djurovic, S.; Foo, J.C.; Forstner, A.J.; Frye, M.; Gatt, J.M.; Giegling, I.; Grabe, H.J.; Green, M.J.; Grevet, E.H.; Grigoroiu-Serbanescu, M.; Gutierrez, B.; Guzman-Parra, J.; Hamshere, M.L.; Hartmann, A.M.; Hauser, J.; Heilmann-Heimbach, S.; Hoffmann, P.; Ising, M.; Jones, I.; Jones, L.A.; Jonsson, L.; Kahn, R.S.; Kelsoe, J.R.; Kendler, K.S.; Kloiber, S.; Koenen, K.C.; Kogevinas, M.; Krebs, M.O.; Landén, M.; Leboyer, M.; Lee, P.H.; Levinson, D.F.; Liao, C.; Lissowska, J.; Mayoral, F.; McElroy, S.L.; McGrath, P.; McGuffin, P.; McQuillin, A.; Mehta, D.; Melle, I.; Mitchell, P.B.; Molina, E.; Morken, G.; Nievergelt, C.; Nöthen, M.M.; O'Donovan, M.C.; Ophoff, R.A.; Owen, M.J.; Pato, C.; Pato, M.T.; Penninx, BWJH; Potash, J.B.; Power, R.A.; Preisig, M.; Quested, D.; Ramos-Quiroga, J.A.; Reif, A.; Ribasés, M.; Richarte, V.; Rietschel, M.; Rivera, M.; Roberts, A.; Roberts, G.; Rouleau, G.A.; Rovaris, D.L.; Sanders, A.R.; Schofield, P.R.; Schulze, T.G.; Scott, L.J.; Serretti, A.; Shi, J.; Sirignano, L.; Sklar, P.; Smeland, O.B.; Smoller, J.W.; Sonuga-Barke, EJS; Trzaskowski, M.; Tsuang, M.T.; Turecki, G.; Vilar-Ribó, L.; Vincent, J.B.; Völzke, H.; Walters, JTR; Weickert, C.S.; Weickert, T.W.; Weissman, M.M.; Williams, L.M.; Wray, N.R.; Zai, C.C.; Agerbo, E.; Børglum, A.D.; Breen, G.; Demontis, D.; Erlangsen, A.; Gelernter, J.; Glatt, S.J.; Hougaard, D.M.; Hwu, H.G.; Kuo, P.H.; Lewis, C.M.; Li, Q.S.; Liu, C.M.; Martin, N.G.; McIntosh, A.M.; Medland, S.E.; Mors, O.; Nordentoft, M.; Olsen, C.M.; Porteous, D.; Smith, D.J.; Stahl, E.A.; Stein, M.B.; Wasserman, D.; Werge, T.; Whiteman, D.C.; Willour, V.; Coon, H.; Beckham, J.C.; Kimbrel, N.A.; Ruderfer, D.M. |
| Contributors: |
VA Million Veteran Program (MVP); MVP Suicide Exemplar Workgroup; Suicide Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Eating Disorder Working Group of the Psychiatric Genomics Consortium; German Borderline Genomics Consortium |
| Publication Year: |
2023 |
| Collection: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Subject Terms: |
Humans; Genome-Wide Association Study; Suicide; Attempted; Depressive Disorder; Major/genetics; Risk Factors; Suicidal Ideation; Polymorphism; Single Nucleotide/genetics; Genetic Predisposition to Disease/genetics; Genetic Loci/genetics; Biological Markers; Depressive Disorders; Genetics; Schizophrenia Spectrum and Other Psychotic Disorders; Self-Harm |
| Description: |
Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1535-7228 |
| Relation: |
The American Journal of Psychiatry; https://iris.unil.ch/handle/iris/178727; serval:BIB_B439E586D149 |
| DOI: |
10.1176/appi.ajp.21121266 |
| Availability: |
https://iris.unil.ch/handle/iris/178727; https://doi.org/10.1176/appi.ajp.21121266 |
| Accession Number: |
edsbas.DDAFF30B |
| Database: |
BASE |