| Title: |
Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli |
| Authors: |
Ryu, Youngjae; Wague, Aboubacar; Liu, Xuhui; Feeley, Brian T; Ferguson, Adam R; Morioka, Kazuhito |
| Contributors: |
Neurobiology |
| Source: |
Frontiers in molecular neuroscience ; 17 ; 1427070 ; Switzerland |
| Publication Year: |
2026 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
cellular signaling; mechanical stress; mechanosensor; mechanotransduction; nervous system |
| Description: |
Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, studies on mechanical stress have highlighted key pathophysiological mechanisms underlying traumatic injury and neurodegenerative diseases. However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the wide variety of methods and definitions used in research. Additionally, as mechanical stimulation techniques such as ultrasound and electromagnetic stimulation are increasingly utilized in psychological and neurorehabilitation treatments, it is vital to understand the underlying biological mechanisms in order to develop accurate pathophysiological models and enhance therapeutic interventions. This review aims to summarize the cellular signaling pathways activated by various mechanical and electromagnetic stimuli with a particular focus on the mammalian nervous system. Furthermore, we briefly discuss potential cellular mechanosensors involved in these processes. ; No embargo |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Frontiers in Molecular Neuroscience; https://doi.org/10.3389/fnmol.2024.1427070; Ryu Y, Wague A, Liu X, Feeley BT, Ferguson AR, Morioka K. Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli. Front Mol Neurosci. 2024 Oct 4;17:1427070. doi:10.3389/fnmol.2024.1427070. PMID: 39430293; PMCID: PMC11486767.; https://hdl.handle.net/20.500.14038/55053 |
| DOI: |
10.3389/fnmol.2024.1427070 |
| Availability: |
https://doi.org/10.3389/fnmol.2024.1427070; https://hdl.handle.net/20.500.14038/55053 |
| Rights: |
© 2024 Ryu, Wague, Liu, Feeley, Ferguson and Morioka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.DDC60036 |
| Database: |
BASE |