| Title: |
Ankle-Brachial Index and cardiovascular events in atrial fibrillation: The ARAPACIS study |
| Authors: |
Violi Francesco; Davì Giovanni; Proietti Marco; Pastori Daniele; Hiatt William R.; Corazza Gino Roberto; Perticone Francesco; Pignatelli Pasquale; Farcomeni Alessio; Vestri Anna Rita; Lip Gregory Y. H.; Basili Stefania; ARAPACIS study investigators; Sacerdoti David |
| Contributors: |
Violi, Francesco; Davì, Giovanni; Proietti, Marco; Pastori, Daniele; Hiatt William, R.; Corazza Gino, Roberto; Perticone, Francesco; Pignatelli, Pasquale; Farcomeni, Alessio; Vestri Anna, Rita; Lip Gregory, Y. H.; Basili, Stefania; ARAPACIS study, Investigator; Sacerdoti, David |
| Publication Year: |
2016 |
| Collection: |
Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: |
ABI; ARAPACIS; Atrial fibrillation; Myocardial infarction; Vascular event; Hematology |
| Description: |
Atrial fibrillation (AF) patients are at high risk for thrombotic and vascularevents related to their cardiac arrhythmia and underlying systemicatherosclerosis. Ankle-Brachial Index (ABI) is a non-invasive tool in evaluating systemic atherosclerosis, useful in predicting cardiovascular events in generalpopulation; no data are available in AF patients. ARAPACIS is a prospectivemulticentre observational study performed by the Italian Society of InternalMedicine, analysing association between low ABI (≤ 0.90) and vascular events inNVAF out- or in-patients, enrolled in 136 Italian centres. A total of 2,027non-valvular AF (NVAF) patients aged > 18 years from both sexes followed for amedian time of 34.7 (interquartile range: 22.0-36.0) months, yielding a total of 4,614 patient-years of observation. Mean age was 73 ± 10 years old with 55 % malepatients. A total of 176 patients (8.7 %) experienced a vascular event, with acumulative incidence of 3.81 %/patient-year. ABI≤ 0.90 was more prevalent inpatients with a vascular event compared with patients free of vascular events(32.2 vs 20.2 %, p< 0.05). On Cox proportional hazard analysis, ABI≤ 0.90 was an independent predictor of vascular events (hazard ratio (HR): 1.394, 95 %confidence interval (CI): 1.042-1.866; p=0.02), vascular death (HR: 2.047, 95 %CI: 1.255-3.338; p=0.004) and MI (HR: 2.709, 95 % CI: 1.485-5.083; p=0.001). Thislatter association was also confirmed after excluding patients with previous MI(HR: 2.901, 95 % CI: 1.408-5.990, p=0.004). No association was observed betweenlow ABI and stroke/transient ischaemic attack (p=0.91). In conclusion, low ABI isuseful to predict MI and vascular death in NVAF patients and may independentlyfacilitate cardiovascular risk assessment in NVAF patients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/26740316; info:eu-repo/semantics/altIdentifier/wos/WOS:000373862900016; volume:115; issue:4; firstpage:856; lastpage:863; numberofpages:8; journal:THROMBOSIS AND HAEMOSTASIS; https://hdl.handle.net/11562/1011715; http://www.schattauer.de/index.php?id=5236&mid=25399 |
| DOI: |
10.1160/TH15-07-0612 |
| Availability: |
https://hdl.handle.net/11562/1011715; https://doi.org/10.1160/TH15-07-0612; http://www.schattauer.de/index.php?id=5236&mid=25399 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.DDD5CF1E |
| Database: |
BASE |