Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
| Title: | Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits |
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| Authors: | Teumer A; Qi Q; Nethander M; Aschard H; Bandinelli S; Beekman M; Berndt SI; Bidlingmaier M; Broer L; CHARGE Longevity Working Group; Cappola A; Ceda GP; Chanock S; Chen MH; Chen TC; Chen YD; Chung J; Del Greco M F; Eriksson J; Ferrucci L; Friedrich N; Gnewuch C; Goodarzi MO; Grarup N; Guo T; Hammer E; Hayes RB; Hicks AA; Hofman A; Houwing-Duistermaat JJ; Hu F; Hunter DJ; Husemoen LL; Isaacs A; Jacobs KB; Janssen JA; Jansson JO; Jehmlich N; Johnson S; Juul A; Karlsson M; Kilpelainen TO; Kovacs P; Kraft P; Li C; Linneberg A; Liu Y; Loos RJ; Body Composition Genetics Consortium; Lorentzon M; Lu Y; Maggio M; Magi R; Meigs J; Mellström D; Nauck M; Newman AB; Pollak MN; Pramstaller PP; Prokopenko I; Psaty BM; Reincke M; Rimm EB; Rotter JI; Saint-Pierre A; Schurmann C; Seshadri S; Sjögren K; Slagboom PE; Strickler HD; Stumvoll M; Suh Y; Sun Q; Zhang C; Svensson J; Tanaka T; Tare A; Tönjes A; Uh HW; van Duijn CM; van Heemst D; Vandenput L; Vasan RS; Völker U; Willems SM; Ohlsson C; Wallaschofski H; Kaplan RC |
| Publication Year: | 2016 |
| Collection: | Free University of Bozen-Bolzano (UNIBZ): BIA (Bozen-Bolzano Institutional Archive) |
| Description: | The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype-phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90 years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci. ; open |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1474-9718 |
| Relation: | http://dx.doi.org/10.1111/acel.12490; http://hdl.handle.net/10863/6436 |
| DOI: | 10.1111/acel.12490 |
| Availability: | http://hdl.handle.net/10863/6436; https://doi.org/10.1111/acel.12490 |
| Rights: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Accession Number: | edsbas.DDE29E93 |
| Database: | BASE |