| Title: |
Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients. |
| Authors: |
Murray, SM; Pose, E; Wittner, M; Londoño, M-C; Schaub, G; Cook, J; Dimitriadis, S; Meacham, G; Irwin, S; Lim, Z; Duengelhoef, P; Sterneck, M; Lohse, AW; Perez, V; Trivedi, P; Bhandal, K; Mullish, BH; Manousou, P; Provine, NM; Avitabile, E; Carroll, M; Tipton, T; Healy, S; Burra, P; Klenerman, P; Dunachie, S; Kronsteiner, B; Maciola, AK; Pasqual, G; Hernandez-Gea, V; Garcia-Pagan, JC; Lampertico, P; Iavarone, M; Gines, P; Lütgehetmann, M; Schulze Zur Wiesch, J; Russo, FP; Barnes, E; Marjot, T; OCTAVE Collaborative Group, PITCH study, and the EASL supported |
| Publisher Information: |
Elsevier |
| Publication Year: |
2024 |
| Collection: |
St George's University of London: Repository |
| Description: |
BACKGROUND & AIMS: Comparative assessments of immunogenicity following different COVID-19 vaccines in patients with distinct liver diseases are lacking. SARS-CoV-2-specific T-cell and antibody responses were evaluated longitudinally after one to three vaccine doses, with long-term follow-up for COVID-19-related clinical outcomes. METHODS: A total of 849 participants (355 with cirrhosis, 74 with autoimmune hepatitis [AIH], 36 with vascular liver disease [VLD], 257 liver transplant recipients [LTRs] and 127 healthy controls [HCs]) were recruited from four countries. Standardised immune assays were performed pre and post three vaccine doses (V1-3). RESULTS: In the total cohort, there were incremental increases in antibody titres after each vaccine dose (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| ISSN: |
1600-0641 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/116265/1/1-s2.0-S0168827823051747-main.pdf; https://openaccess.sgul.ac.uk/id/eprint/116265/6/1-s2.0-S0168827823051747-mmc1.pdf; https://openaccess.sgul.ac.uk/id/eprint/116265/11/1-s2.0-S0168827823051747-mmc2.docx; https://openaccess.sgul.ac.uk/id/eprint/116265/13/1-s2.0-S0168827823051747-mmc3.pdf; https://openaccess.sgul.ac.uk/id/eprint/116265/18/1-s2.0-S0168827823051747-mmc4.pdf; Murray, SM; Pose, E; Wittner, M; Londoño, M-C; Schaub, G; Cook, J; Dimitriadis, S; Meacham, G; Irwin, S; Lim, Z; et al. Murray, SM; Pose, E; Wittner, M; Londoño, M-C; Schaub, G; Cook, J; Dimitriadis, S; Meacham, G; Irwin, S; Lim, Z; Duengelhoef, P; Sterneck, M; Lohse, AW; Perez, V; Trivedi, P; Bhandal, K; Mullish, BH; Manousou, P; Provine, NM; Avitabile, E; Carroll, M; Tipton, T; Healy, S; Burra, P; Klenerman, P; Dunachie, S; Kronsteiner, B; Maciola, AK; Pasqual, G; Hernandez-Gea, V; Garcia-Pagan, JC; Lampertico, P; Iavarone, M; Gines, P; Lütgehetmann, M; Schulze Zur Wiesch, J; Russo, FP; Barnes, E; Marjot, T; OCTAVE Collaborative Group, PITCH study, and the EASL supported (2024) Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients. J Hepatol, 80 (1). pp. 109-123. ISSN 1600-0641 https://doi.org/10.1016/j.jhep.2023.10.009 SGUL Authors: Koh, Mickey |
| DOI: |
10.1016/j.jhep.2023.10.009 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/116265/; https://doi.org/10.1016/j.jhep.2023.10.009 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.DDFBF1D8 |
| Database: |
BASE |