| Title: |
Clinical relevance of enteropathogen co-infections in preschool children: a population-based repeated cross-sectional study |
| Authors: |
Pijnacker, R; van Pelt, W; Vennema, H; Kortbeek, L M; Notermans, D W; Franz, E; Mughini-Gras, L; Sub Dynamics Meteorology; One Health Microbieel; dIRAS RA-I&I I&I |
| Publication Year: |
2019 |
| Subject Terms: |
Child; Preschool; Coinfection/epidemiology; Cross-Sectional Studies; Dientamoebiasis/epidemiology; Enteropathogenic Escherichia coli; Escherichia coli Infections/epidemiology; Family Characteristics; Feces/microbiology; Female; Gastroenteritis/epidemiology; Humans; Infant; Newborn; Male; Netherlands/epidemiology; Risk Factors; Rotavirus Infections/epidemiology; Taverne |
| Description: |
OBJECTIVES: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children. METHODS: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012 to October 2014. A total of 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors; 822 samples were successfully tested for 19 enteropathogens using real-time multiplex PCRs. Logistic regression analysis assessed co-infections in relation to gastroenteritis and potential risk factors. RESULTS: In all, 598/822 (72.7%) stool samples tested positive for at least one enteropathogen, of which 290 (48.5%) were positive for two or more enteropathogens. Risk factors for two or more enteropathogen co-infections were young age ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1198-743X |
| Relation: |
https://dspace.library.uu.nl/handle/1874/387739 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/387739 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.DE55D240 |
| Database: |
BASE |