| Title: |
Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial |
| Authors: |
Hochman, Judith S.; Reynolds, Harmony R.; Bangalore, Sripal; O'Brien, Sean M.; Alexander, Karen P.; Senior, Roxy; Boden, William E.; Stone, Gregg W.; Goodman, Shaun G.; Lopes, Renato D.; Lopez-Sendon, Jose; White, Harvey D.; Maggioni, Aldo P.; Shaw, Leslee J.; Min, James K.; Picard, Michael H.; Berman, Daniel S.; Chaitman, Bernard R.; Mark, Daniel B.; Spertus, John A.; Cyr, Derek D.; Bhargava, Balram; Ruzyllo, Witold; Wander, Gurpreet S.; Chernyavskiy, Alexander M.; Rosenberg, Yves D.; Maron, David J.; Mavromatis, Kreton; Miller, Todd; Banerjee, Subhash; Abdul-Nour, Khaled; Stone, Peter H.; Jang, James J.; Weitz, Steven; Arnold, Suzanne; Shapiro, Michael D.; El-Hajjar, Mohammad; McFalls, Edward O.; Khouri, Michel Georges; Goldberg, Jonathan L.; Goldweit, Richard; Cohen, Ronny A.; Winchester, David E.; Kronenberg, Marvin; Heitner, John F.; Dauber, Ira M.; Cannan, Charles; Sudarshan, Sriram; Mehta, Puja K.; Hedgepeth, Chester M.; Sahul, Zakir; Booth, David; Setty, Sampoornima; Barua, Rajat S.; Hage, Fadi; Dajani, Khaled; Arif, Imran; Trejo (Gutierrez), Jorge F.; Gemignani, Anthony; Meadows, Judith L.; Call, Jason T.; Hannan, Joseph; Martin, Edward T.; Vorobiof, Gabriel; Moorman, Alec; Kinlay, Scott; Rayos, Glenn; Seedhom, Ashraf; Kumkumian, Gregory; Sedlis, Steven P.; Tamis-Holland, Jacqueline E.; Saba, Souheil; Badami, Umesh; Marzo, Kevin; Robbins, Inga H.; Hamroff, Glenn S.; Little, Raymond W.; Lui, Charles Y.; Hu, Bob; Labovitz, Arthur J.; Rodriguez, Fatima; Deedwania, Prakash; Sweeny, Joseph; Spizzieri, Christopher; Hochberg, Claudia P.; Salerno, William D.; Wyman, Ray; Zarka, Amer; Haldis, Thomas; Kohn, Jeffrey A.; Girotra, Saket; Almousalli, Omar; Krishnam, Mayil S.; Coram, Rita; Thomas, Sabu; El Shahawy, Mahfouz; Stafford, James; Abernethy, William B.; Zurick, Andrew; Meyer, Thomas M.; Rutkin, Bruce; Bokhari, Sabahat; Sokol, Seth I.; Hamzeh, Ihab; Turner, Michael C.; Good, Arnold P.; Shammas, Nicolas W.; Chilton, Robert; Nguyen, Patricia K.; Jezior, Matthew; Gordon, Paul C.; Stenberg, Robert; Pedalino, Ronald P.; Wiesel, Joseph; Juang, George J.; Al-Amoodi, Mohammed; Wohns, David; Lader, Ellis W.; Mumma, Michael; Dharmarajan, Lekshmi; McGarvey, Joseph F.X.; Downes, Thomas R.; Cheong, Benjamin; Potluri, Srinivasa; Mastouri, Ronald A.; Li, Dayuan; Giedd, Kenneth; Old, Wayne; Burt, Francis; Sokhon, Kozhaya; Gopal, Deepika; Valeti, Uma S.; Kobashigawa, Jon; Govindan, Sajeev Chakanalil; Manjunath, Cholenahally Nanjappa; Pandit, Neeraj; Dwivedi, S.K.; Mathew, Anoop; Gadkari, Milind Avdhoot; Satheesh, Santhosh; Mathur, Atul; Christopher, Johann; Oomman, Abraham; Naik, Sudhir; Grant, Purvez; Kachru, Ranjan; Kumar, Ajit; Kaul, Upendra; Gamma, Reto Andreas; de Belder, Mark A.; Nageh, Thuraia; Lindsay, Steven J.; Hoye, Angela; Donnelly, Patrick; Chauhan, Anoop; Barr, Craig; Alfakih, Khaled; Henriksen, Peter; Okane, Peter; de Silva, Ramesh; Conway, Dwayne S.G.; Sirker, Alexander A.; Hoole, Stephen P.; Witherow, Fraser N.; Johnston, Nicola; Luckie, Matthew; Sobolewska, Jolanta; Jeetley, Paramjit; Travill, Christopher; Braganza, Denise; Henderson, Robert; Berry, Colin; Moriarty, Andrew J.; Glover, Jason D.; Mikhail, Ghada; Gosselin, Gilbert; Diaz, Ariel; Phaneuf, Denis Carl; Garg, Pallav; Chow, Benjamin J.W.; Bainey, Kevin R.; Cheema, Asim N.; Cheema, Asim Nazir; Cha, James; Howarth, Andrew G.; Wong, Graham; Uxa, Amar; Galiwango, Paul; Lam, Andy; Mehta, Shamir; Udell, Jacob; Genereux, Philippe; Hameed, Adnan; Daba, Ledjalem; Hueb, Whady; Smanio, Paola Emanuela Poggio; de Quadros, Alexandre Schaan; Vitola, Joao V.; Marin-Neto, Jose Antonio; Polanczyk, Carisi A.; Carvalho, Antonio Carlos; Alves Junior, Alvaro Rabelo; Dracoulakis, Marianna D.A.; Figueiredo, Estevao; Caramori, Paulo Ricardo; Tumelero, Rogerio; Dall'Orto, Frederico; Mesquita, Claudio T.; Ribeiro da Silva, Expedito Eustaquio; Saraiva, Jose Francisco; Costantini, Costantino; Demkow, Marcin; Mazurek, Tomasz; Drozdz, Jaroslaw; Szwed, Hanna; Witkowski, Adam; Gajos, Grzegorz; Pruszczyk, Piotr; Loboz-Grudzien, Krystyna; Lesiak, Maciej; Reczuch, Krzysztof W.; Kalarus, Zbigniew; Musial, Wlodzimierz J.; Bockeria, Leo; Bershtein, Leonid L.; Demchenko, Elena A.; Lopez-Sendon, Jose Luis; Peteiro, Jesus; Gonzalez Juanatey, Jose Ramon; Sionis, Alessandro; Miro, Vicente; Ortuno, F. Marin; Blancas, Montserrat Gracida; Luena, Jose Enrique Castillo; Fernandez-Aviles, Francisco; Chen, Jiyan; Wu, Yongjian; Ma, Yitong; Ji, Zheng; Yang, Xinchun; Lin, Wenhua; Zeng, Hesong; Fu, Xin; Yang, Bin; Wang, Songtao; Cheng, Gong; Zhao, Yulan; Fang, Xuehua; Zeng, Qiutang; Su, Xi; Li, Qingxian; Nie, Shao-Ping; Yu, Qin; Wang, Jian'an; Zhang, Shuyang; Perna, Gian Piero; Provasoli, Stefano; Monti, Lorenzo; Di Chiara, Antonio; Mortara, Andrea; Galvani, Marcello; Sicuro, Marco; Calabro, Paolo; Tarantini, Giuseppe; Racca, Emanuela; Briguori, Carlo; Amati, Roberto; Russo, Aldo; Poh, Kian-Keong; Foo, David; Chua, Terrance; Doerr, Rolf; Sechtem, Udo; Schulze, P. Christian; Nickenig, Georg; Schuchlenz, Herwig; Lang, Irene Marthe; Huber, Kurt; Vertes, Andras; Varga, Albert; Fontos, Geza; Merkely, Bela; Kerecsen, Gabor; Hinic, Sasa; Beleslin, Branko D.; Cemerlic-Adjic, Nada; Davidovic, Goran; Dekleva, Milica Nikola; Stankovic, Goran; Apostolovic, Svetlana; Escobedo, Jorge; Rosas, Erick Alexanderson; Selvanayagam, Joseph B.; Thambar, Suku T.; Beltrame, John F.; Hillis, Graham S.; Thuaire, Christophe; Steg, Philippe-Gabriel; Slama, Michel S.; El Mahmoud, Rami; Nicollet, Eric; Barone-Rochette, Gilles; Furber, Alain; Laucevicius, Aleksandras; Kedhi, Elvin; Riezebos, Robert K.; Suryapranata, Harry; Ramos, Ruben; Pinto, Fausto J.; Ferreira, Nuno; Guzman, Luis; Figal, Julio Cesar; Alvarez, Carlos; Courtis, Javier; Schiavi, Lilia; Rubio, Mariano; Devlin, Gerard Patrick; Stewart, Ralph Alan Huston; Kedev, Sasko; Held, Claes; Aspberg, Johannes; Sharir, Tali; Kerner, Arthur; Fukuda, Keiichi; Yasuda, Satoshi; Nishimura, Shigeyuki; Goetschalckx, Kaatje; Hung, Chung-Lieh; Ntsekhe, Mpiko; Moccetti, Tiziano; Abdelhamid, Magdy; Pop, Calin; Popescu, Bogdan A.; Al-Mallah, Mouaz H.; Ramos, Walter Enrique Mogrovejo; Kuanprasert, Srun; Yamwong, Sukit; Khairuddin, Ahmad; Ferguson, Bruce; Harrington, Robert; Williams, David; Berger, Jeffrey; Newman, Jonathan; Sidhu, Mandeep; Dzavik, Vladimir; Jiang, Lixin; Keltai, Matyas; Kohsaka, Shun; Maggioni, Aldo; Mancini, G.B. John; Merz, C. Noel Bairey; Weintraub, William; Ballantyne, Christie; Calfas, Karen J.; Davidson, Michael; Friedrich, Matthias; Hachamovitch, Rory; Kwong, Raymond; Harrell, Frank; Kullo, Iftikhar; McManus, Bruce; Cohen, David J.; Bugiardini, Raffaele; Celutkiene, Jelena; Lyubarova, Radmila; Mattina, Deirdre; Nwosu, Samuel; Broderick, Samuel; Cyr, Derek; Rockhold, Frank; Anstrom, Kevin; Jones, Philip; Phillips, Lawrence; Hayes, Sean W.; Friedman, John D.; Gerlach, R. James; Kwong, Raymond Y.; Mongeon, Francois Pierre; Hung, Judy; Scherrer-Crosbie, Marielle; Zeng, Xin; Ali, Ziad; Arsanjani, Reza; Budoff, Matthew; Leipsic, Jonathan; Nakanishi, Rine; Youn, Tricia; Orso, Francesco; Zhang, Haibo; Zhang, Lihua; Diaz, Rafael; Van de Werf, Frans; Fleg, Jerome; Kirby, Ruth; Jeffries, Neal |
| Source: |
ISSN:2380-6583 ; ISSN:2380-6591 ; Jama Cardiology, vol. 4 (3), (273-286. |
| Publisher Information: |
American Medical Association |
| Publication Year: |
2019 |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; CORONARY-ARTERY-DISEASE; MEDICAL THERAPY; PROGNOSTIC VALUE; REVASCULARIZATION; OUTCOMES; BENEFIT; ECHOCARDIOGRAPHY; IMPACT; SCORE; PCI; Aged; Angina Pectoris; Cardiovascular Diseases; Computed Tomography Angiography; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Prognosis; Risk Assessment |
| Description: |
IMPORTANCE: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE: To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. DESIGN, SETTING, AND PARTICIPANTS: The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/20.500.12942/725542; https://doi.org/10.1001/jamacardio.2019.0014; https://pubmed.ncbi.nlm.nih.gov/30810700 |
| DOI: |
10.1001/jamacardio.2019.0014 |
| Availability: |
https://lirias.kuleuven.be/handle/20.500.12942/725542; https://hdl.handle.net/20.500.12942/725542; https://doi.org/10.1001/jamacardio.2019.0014; https://pubmed.ncbi.nlm.nih.gov/30810700 |
| Rights: |
info:eu-repo/semantics/restrictedAccess ; intranet |
| Accession Number: |
edsbas.DED62FB5 |
| Database: |
BASE |