| Title: |
COVID-19 Vaccination: Impact on Disease Severity and Mortality in an African Setting |
| Authors: |
Chiabi, Andreas; Unji, Princewill Kum; Tatang, Alex Mambap; Angwafor, Samuel; Niba, Loveline Lu; Porro, Minette Jaqueline Adji; Nforniwe, Denis Nsame |
| Publisher Information: |
Reial Acadèmia de Medicina de les Illes Balears |
| Publication Year: |
2023 |
| Collection: |
Universitat de les Illes Balears: Biblioteca Digital |
| Subject Terms: |
COVID-19 Pandemic; 2020-; Vaccines; Health Sciences; Medicine |
| Description: |
[eng] Objectives: Ending the current COVID-19 pandemic entails attaining herd immunity, requiring high vaccination rates. However, vaccination rates remain very low in our setting, vaccine hesitancy due to lack of sufficient data on actual benefits of being vaccinated being a major cause. This study aimed at assessing the benefits of COVID-19 vaccination on disease severity and mortality. Methods: Retrospective cohort study for COVID-19 patients managed by the Bamenda Regional Hospital from August 2021 to February 2022, using regression to asses relationship between vaccination status and disease severity, as well as mortality. Results: The 1389 participants included in our study had a mean age of 49.5 (±19.5) years and a female predominance 60.2% (836). A total of 81(5.8%) patients were fully vaccinated and 77(5.5%) were partially vaccinated. Overall, 485(34.9%) had comorbidities, 419(30.2%) were admitted with moderate to severe disease, among which 137(32.7%) died. Among patients admitted with moderate to severe disease, only 2 (0.5%) were fully vaccinated and 6 (1.4%) partially vaccinated, where those fully vaccinated had lower odds of having severe disease (OR =0.05; CI95 (0.01-0.18); p=0.000), as well as partially vaccinated (OR =0.15; CI95 (0.06-0.35); p=0.000). Among patients who died, only 2 (1.5%) were partially vaccinated and none fully vaccinated, where being vaccinated (partially) did not affect odds of mortality (OR =1.02; CI95 (0.19-5.65); p=0.980). Conclusion: Being fully vaccinated and to a lesser extent partially vaccinated was associated with lower odds for severe disease. As for mortality, complete vaccination was suggestive for being protective while partial vaccination had no effect. ; [spa] Objetivos: Poner fin a la actual pandemia de COVID-19 implica lograr la inmunidad colectiva, lo que requiere altas tasas de vacunación. Sin embargo, las tasas de vacunación siguen siendo muy bajas en nuestro medio, siendo la reticencia a la vacunación por falta de datos suficientes sobre los beneficios ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Academic Journal of Health Sciences 2023, Vol. 38, n. 3, pp. 142-147; http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/AJHS_Medicina_Balear_2023v38n3p142 |
| DOI: |
10.3306/AJHS.2023.38.03.142 |
| Availability: |
https://doi.org/10.3306/AJHS.2023.38.03.142; http://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/AJHS_Med/icina_Ba/lear_202/3v38n3p1/42.dir/AJHS_Medicina_Balear_2023v38n3p142.pdf; http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/AJHS_Medicina_Balear_2023v38n3p142 |
| Rights: |
All rights reserved ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.DF111F23 |
| Database: |
BASE |