Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy
| Title: | Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy |
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| Authors: | Rasing, Ingeborg; Vlegels, Naomi; Schipper, Manon R.; Voigt, Sabine; Koemans, Emma A.; Kaushik, Kanishk; van Dort, Rosemarie; van Harten, Thijs W.; De Luca, Alberto; van Etten, Ellis S.; van Zwet, Erik W.; van Buchem, Mark A.; Middelkoop, Huub A.M.; Biessels, Geert Jan; Terwindt, Gisela M.; van Osch, Matthias J.P.; van Walderveen, Marianne A.A.; Wermer, Marieke J.H. |
| Source: | Rasing, I, Vlegels, N, Schipper, M R, Voigt, S, Koemans, E A, Kaushik, K, van Dort, R, van Harten, T W, De Luca, A, van Etten, E S, van Zwet, E W, van Buchem, M A, Middelkoop, H A M, Biessels, G J, Terwindt, G M, van Osch, M J P, van Walderveen, M A A & Wermer, M J H 2024, 'Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy', Journal of Cerebral Blood Flow and Metabolism, vol. 44, no. 11, pp. 1253-1261. https://doi.org/10.1177/0271678X241261771 |
| Publication Year: | 2024 |
| Collection: | University of Groningen research database |
| Subject Terms: | Cerebral amyloid angiopathy; cognitive impairment; diffusion magnetic resonance imaging; Dutch-type hereditary cerebral amyloid angiopathy; MRI CAA-small vessel disease burden |
| Description: | Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/symptomatic; mean age 39/58 y). PSMD-levels increased with disease severity and were higher in symptomatic D-CAA mutation-carriers (median [range] 4.90 [2.77–9.50]mm 2 /s × 10 −4 ) compared with presymptomatic mutation-carriers (2.62 [1.96–3.43]mm 2 /s × 10 −4 ) p = |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0271-678X |
| Relation: | info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/70079bb0-de8c-43eb-8253-76790c36e00c; info:eu-repo/semantics/altIdentifier/pissn/0271-678X |
| DOI: | 10.1177/0271678X241261771 |
| Availability: | https://hdl.handle.net/11370/70079bb0-de8c-43eb-8253-76790c36e00c; https://research.rug.nl/en/publications/70079bb0-de8c-43eb-8253-76790c36e00c; https://doi.org/10.1177/0271678X241261771; https://pure.rug.nl/ws/files/1181708807/rasing-et-al-2024-microstructural-white-matter-damage-on-mri-is-associated-with-disease-severity-in-dutch-type-cerebral.pdf; https://www.scopus.com/pages/publications/85196421551 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: | edsbas.DF27ED9 |
| Database: | BASE |