| Title: |
Dysregulation of lipid mediators in patients with frequent exacerbations of chronic obstructive pulmonary disease |
| Authors: |
Fisk, Marie; Gomez, Esteban A; Sun, Yuan; Mickute, Monika; McEniery, Carmel; Cockcroft, John R; Bolton, Charlotte; Fuld, Jonathan; Cheriyan, Joseph; MacNee, Yasmin,William; Tal-Singer, Ruth; Polkey, Michael; Wilkinson, Ian; Dalli, Jesmond |
| Publisher Information: |
European Respiratory Society |
| Publication Year: |
2025 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
IntroductionSpecialised pro-resolving mediators (SPMs) are endogenously produced lipid mediators (LMs) that regulate the propagation of inflammation and promote tissue repair. We hypothesised that SPM production is dysregulated in COPD and is associated with disease severity, defined by patients with stable COPD (no exacerbations) versus patients with frequent exacerbations.MethodsLMs were measured in plasma samples from patients with COPD (stable patients and patients with frequent exacerbations) and from healthy controls, matched for age, sex and body mass index, using liquid chromatography–tandem mass spectrometry (LC-MS/MS). The LM profiles of controls were compared with those of stable COPD patients, and the LM profiles of stable COPD patients were compared with those of COPD patients with frequent exacerbations. We explored whether or not there was an association between LM profile and ever having a severe COPD exacerbation over 4.1 years of follow-up. Data are presented as mean±sem in pg·mL−1 for LMs, or mean±sd.Results49 stable COPD patients had increased levels of pro-inflammatory mediators and some SPMs, compared with 28 controls (prostaglandin (PG)D2: 13.97±2.44 versus 0.53±0.13; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/44078098; ERJ Open Research; Volume 11; Issue 2 |
| DOI: |
10.1183/23120541.00950-2023 |
| Availability: |
https://doi.org/10.1183/23120541.00950-2023; https://nottingham-repository.worktribe.com/file/44078098/1/Dysregulation%20of%20lipid%20mediators%20in%20patients%20with%20frequent%20exacerbations%20of%20COPD; https://nottingham-repository.worktribe.com/output/44078098 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.DF499F24 |
| Database: |
BASE |