| Title: |
A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam |
| Authors: |
Campbell, Ciarán; McCormack, Mark; Patel, Sonn; Stapleton, Caragh; Bobbili, Dheeraj; Krause, Roland; Depondt, Chantal; Sills, Graeme J; Koeleman, Bobby P; Striano, Pasquale; Zara, Federico; Sander, Josemir W; Lerche, Holger; Kunz, Wolfram S; Stefansson, Kari; Stefansson, Hreinn; Doherty, Colin P; Heinzen, Erin L; Scheffer, Ingrid E; Goldstein, David B; O'Brien, Terence; Cotter, David; Berkovic, Samuel F; Sisodiya, Sanjay M; Delanty, Norman; Cavalleri, Gianpiero L |
| Contributors: |
Campbell, Ciarán; Mccormack, Mark; Patel, Sonn; Stapleton, Caragh; Bobbili, Dheeraj; Krause, Roland; Depondt, Chantal; Sills, Graeme J; Koeleman, Bobby P; Striano, Pasquale; Zara, Federico; Sander, Josemir W; Lerche, Holger; Kunz, Wolfram S; Stefansson, Kari; Stefansson, Hreinn; Doherty, Colin P; Heinzen, Erin L; Scheffer, Ingrid E; Goldstein, David B; O'Brien, Terence; Cotter, David; Berkovic, Samuel F; Sisodiya, Sanjay M; Delanty, Norman; Cavalleri, Gianpiero L |
| Publisher Information: |
John Wiley & Sons; USA; Hoboken |
| Publication Year: |
2022 |
| Collection: |
Università degli Studi di Genova: CINECA IRIS |
| Subject Terms: |
adverse drug reaction; levetiracetam; pharmacogenomic; polygenic risk scoring; psychosi; Anticonvulsant; Case-Control Studie; Genetic Predisposition to Disease; Human; Pharmacogenetic; Prospective Studie; Drug-Related Side Effects and Adverse Reaction; Genome-Wide Association Study |
| Description: |
Levetiracetam (LEV) is an effective antiseizure medicine, but 10%-20% of people treated with LEV report psychiatric side-effects, and up to 1% may have psychotic episodes. Pharmacogenomic predictors of these adverse drug reactions (ADRs) have yet to be identified. We sought to determine the contribution of both common and rare genetic variation to psychiatric and behavioral ADRs associated with LEV. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35298028; info:eu-repo/semantics/altIdentifier/wos/WOS:000777032200001; volume:63; firstpage:1563; lastpage:1570; numberofpages:8; journal:EPILEPSIA; https://hdl.handle.net/11567/1093124 |
| DOI: |
10.1111/epi.17228 |
| Availability: |
https://hdl.handle.net/11567/1093124; https://doi.org/10.1111/epi.17228 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.DF5479B2 |
| Database: |
BASE |