| Title: |
Sex differences in oncogenic mutational processes |
| Authors: |
Li, CH; Prokopec, SD; Sun, RX; Yousif, F; Schmitz, N; Al-Shahrour, F; Atwal, G; Bailey, PJ; Biankin, AV; Boutros, PC; Campbell, PJ; Chang, DK; Cooke, SL; Deshpande, V; Faltas, BM; Faquin, WC; Garraway, L; Getz, G; Grimmond, SM; Haider, S; Hoadley, KA; Jiao, W; Kaiser, VB; Karlić, R; Kato, M; Kübler, K; Lazar, AJ; Louis, DN; Margolin, A; Martin, S; Nahal-Bose, HK; Nielsen, GP; Nik-Zainal, S; Omberg, L; P’ng, C; Perry, MD; Polak, P; Rheinbay, E; Rubin, MA; Semple, CA; Sgroi, DC; Shibata, T; Siebert, R; Smith, J; Stein, LD; Stobbe, MD; Thai, K; Wright, DW; Wu, CL; Yuan, K; Zhang, J; Aaltonen, LA; Abascal, F; Abeshouse, A; Aburatani, H; Adams, DJ; Agrawal, N; Ahn, KS; Ahn, SM; Aikata, H; Akbani, R; Akdemir, KC; Al-Ahmadie, H; Al-Sedairy, ST; Alawi, M; Albert, M; Aldape, K; Alexandrov, LB; Ally, A; Alsop, K; Alvarez, EG; Amary, F; Amin, SB; Aminou, B; Ammerpohl, O; Anderson, MJ; Ang, Y; Antonello, D; Anur, P; Aparicio, S; Appelbaum, EL; Arai, Y; Aretz, A; Arihiro, K; Ariizumi, SI; Armenia, J; Arnould, L; Asa, S; Assenov, Y; Aukema, S; Auman, JT; Aure, MR; Awadalla, P; Aymerich, M; Bader, GD; Baez-Ortega, A; Pajic, Marina; Merrett, Neil; Pinese, Mark; Lau, Loretta; Gill, Anthony; Toon, Christopher Chien Wei; Chou, Angela; Johns, Amber |
| Source: |
urn:ISSN:2041-1723 ; Nature Communications, 11, 1, 4330 |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2020 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
31 Biological Sciences; 3102 Bioinformatics and Computational Biology; 32 Biomedical and Clinical Sciences; 42 Health Sciences; 3211 Oncology and Carcinogenesis; Women's Health; Cancer; Genetics; Cancer Genomics; Human Genome; 2.1 Biological and endogenous factors; 3 Good Health and Well Being; Chromosomal Instability; Exome; Female; Genome; Human; Genomic Instability; Humans; Logistic Models; Male; Mutation; Neoplasms; Oncogenes; Open Reading Frames; Sex Characteristics; beta Catenin; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium; anzsrc-for: 31 Biological Sciences |
| Description: |
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_73185 |
| DOI: |
10.1038/s41467-020-17359-2 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_73185; https://unsworks.unsw.edu.au/bitstreams/a49151be-fb93-4c7e-8cf6-4c5da1759e79/download; https://unsworks.unsw.edu.au/bitstreams/1808fb07-ba94-49d5-b060-5a60b155af24/download; https://unsworks.unsw.edu.au/bitstreams/b27d7792-ac27-40db-a99a-918d24920de0/download; https://doi.org/10.1038/s41467-020-17359-2 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.DF6C0852 |
| Database: |
BASE |