Protocol for a double-blind placebocontrolled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults
| Title: | Protocol for a double-blind placebocontrolled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults |
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| Authors: | Koychev, Ivan; Adler, Amanda I; Edison, Paul; Tom, Brian D.; Milton, Joanne E; Butchart, Joe; Hampshire, Adam; Marshall, Charles; Coulthard, E J; Zetterberg, Henrik; Hellyer, Peter; Cormack, Francesca K; Underwood, Benjamin R; Mummery, Catherine J; Holman, Rury R. |
| Source: | Koychev, I, Adler, A I, Edison, P, Tom, B D, Milton, J E, Butchart, J, Hampshire, A, Marshall, C, Coulthard, E J, Zetterberg, H, Hellyer, P, Cormack, F K, Underwood, B R, Mummery, C J & Holman, R R 2024, 'Protocol for a double-blind placebocontrolled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults', BMJ. < https://bmjopen.bmj.com/content/14/6/e081401.full > |
| Publication Year: | 2024 |
| Collection: | University of Bristol: Bristol Reserach |
| Description: | Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), currently marketed for type 2 diabetes and obesity, may offer novel mechanisms to delay or prevent neurotoxicity associated with Alzheimer’s disease (AD). The impact of semaglutide in amyloid positivity (ISAP) trial is investigating whether the GLP-1 RA semaglutide reduces accumulation in the brain of cortical tau protein and neuroinflammation in individuals with preclinical/prodromal AD. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1983/d25ab741-e58a-47f0-bd31-21ab4c037592 |
| Availability: | https://hdl.handle.net/1983/d25ab741-e58a-47f0-bd31-21ab4c037592; https://research-information.bris.ac.uk/en/publications/d25ab741-e58a-47f0-bd31-21ab4c037592; https://bmjopen.bmj.com/content/14/6/e081401.full |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.DF74CB08 |
| Database: | BASE |