| Title: |
Short-term effect of air stacking and mechanical insufflation-exsufflation on lung function in patients with neuromuscular diseases |
| Authors: |
Veldhoen, Esther S; Vercoelen,Femke; Ros, Leandra; Verweij-van den Oudenrijn, Laura P; Wösten-van Asperen, Roelie M; Hulzebos, Erik Hj; Bartels, Bart; Gaytant, Michael A; van der Ent, Kors; Ludo van der Pol, W; Intensive care patientenzorg; Child Health; Projectafdeling SvS; Activity&Health sectie exercise; Kinderbewegingszorg patientenzorg; Longziekten; Other research (not in main researchprogram); Longziekten patientenzorg; Speerpunt Child Health; Infection & Immunity; Neurologen; Brain |
| Publication Year: |
2022 |
| Subject Terms: |
Lung function; airway clearance; home care; neuromuscular; Pulmonary and Respiratory Medicine |
| Description: |
Air stacking (AS) and mechanical insufflation-exsufflation (MI-E) aim to increase cough efficacy by augmenting inspiratory lung volumes in patients with neuromuscular diseases (NMDs). We studied the short-term effect of AS and MI-E on lung function. We prospectively included NMD patients familiar with daily AS or MI-E use. Studied outcomes were forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF) prior to, immediately after, and up to 2 h after treatment. Paired sample T-test and Wilcoxon signed-rank test was used. Sixty-seven patients participated. We observed increased FVC and FEV1 immediately after AS with a mean difference of respectively 0.090 L (95% CI 0.045; 0.135, p < .001) and 0.073 L (95% CI 0.017; 0.128, p = .012). Increased FVC immediately after MI-E (mean difference 0.059 L (95% CI 0.010; 0.109, p = .021) persisted 1 hour (mean difference 0.079 L (95% CI 0.034; 0.125, p = .003). The effect of treatment was more pronounced in patients diagnosed with Spinal Muscular Atrophy, compared to patients with Duchenne muscular dystrophy. AS and MI-E improved FVC immediately after treatment, which persisted 1 h after MI-E. There is insufficient evidence that short-lasting increases in FVC would explain the possible beneficial effect of AS and MI-E. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
1479-9723 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/446224 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/446224 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.DF7DE78B |
| Database: |
BASE |