| Title: |
Adults Hospitalized With Coronavirus Disease 2019 (COVID-19)—United States, March–June and October–December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes |
| Authors: |
Sami, Samira; Tenforde, Mark W; Talbot, H Keipp; Lindsell, Christopher J; Steingrub, Jay S; Shapiro, Nathan I; Ginde, Adit A; Douin, David J; Prekker, Matthew E; Erickson, Heidi L; Brown, Samuel M; Peltan, Ithan D; Gong, Michelle N; Khan, Akram; Exline, Matthew C; Files, D Clark; Gibbs, Kevin W; Rice, Todd W; Casey, Jonathan D; Grijalva, Carlos G; Stubblefield, William B; Womack, Kelsey N; Hager, David N; Qadir, Nida; Chang, Steven Y; Henning, Daniel J; Wilson, Jennifer G; Self, Wesley H; Patel, Manish M |
| Source: |
Clinical Infectious Diseases, vol 73, iss Supplement_1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2021 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); Aging (rcdc); Coronaviruses Disparities and At-Risk Populations (rcdc); Immunization (rcdc); Coronaviruses (rcdc); Vaccine Related (rcdc); Clinical Research (rcdc); Infectious Diseases (rcdc); Prevention (rcdc); Emerging Infectious Diseases (rcdc); Lung (rcdc); Social Determinants of Health (rcdc); 3 Good Health and Well Being (sdg); Adolescent (mesh); Adult (mesh); COVID-19 (mesh); COVID-19 Vaccines (mesh); Hospitalization (mesh); Humans (mesh); SARS-CoV-2 (mesh); United States (mesh); Vaccination (mesh); SARS-CoV-2; United States; COVID-19; hospitalization; vaccination |
| Subject Geographic: |
s32 - s37 |
| Description: |
BACKGROUND: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons aged ≥65 years, and persons aged 16-64 years with high-risk medical conditions when there is limited vaccine supply. We compared characteristics and severe outcomes of hospitalized patients with COVID-19 in the United States between early and later in the pandemic categorized by groups at higher risk of severe COVID-19. METHODS: Observational study of sampled patients aged ≥18 years who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and admitted to one of 14 academic hospitals in the United States during March-June and October-December 2020. Demographic and clinical information were gathered from electronic health record data. RESULTS: Among 647 patients, 91% met ≥1 of the following risk factors for severe COVID-19 [91% March-June (n = 434); 90% October-December (n = 213)]; 19% were LTCF residents, 45% were aged ≥65-years, and 84% had ≥1 high-risk condition. The proportion of patients who resided in a LTCF declined significantly (25% vs 6%) from early to later pandemic periods. Compared with patients at lower risk for severe COVID-19, in-hospital mortality was higher among patients at high risk for severe COVID-19 (20% vs 7%); these differences were consistently observed between March-June and October-December. CONCLUSIONS: Most adults hospitalized with COVID-19 were those recommended to be prioritized for vaccination based on risk for developing severe COVID-19. These findings highlight the continued urgency to vaccinate patients at high risk for severe COVID-19 and monitor vaccination impact on hospitalizations and outcomes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt41d695fg; https://escholarship.org/uc/item/41d695fg; https://escholarship.org/content/qt41d695fg/qt41d695fg.pdf |
| DOI: |
10.1093/cid/ciab319 |
| Availability: |
https://escholarship.org/uc/item/41d695fg; https://escholarship.org/content/qt41d695fg/qt41d695fg.pdf; https://doi.org/10.1093/cid/ciab319 |
| Rights: |
public |
| Accession Number: |
edsbas.DF933D62 |
| Database: |
BASE |