| Title: |
Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study |
| Authors: |
Lin, Zi Xuan; Zhang, Xiu Juan; Tang, Fang Yao; Zhang, Yuzhou; Kam, Ka Wai; Young, Alvin L.; Ip, Patrick; Cheung, Carol Y.; Pang, Chi Pui; Tham, Clement C.; Chen, Li Jia; Ohno-Matsui, Kyoko; Yam, Jason C. |
| Publisher Information: |
C.V. Mosby Co. |
| Publication Year: |
2025 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Subject Terms: |
myopia; OCT-A; retinal microvasculature |
| Description: |
PURPOSE. To investigate the associations between optical coherence tomography angiography (OCT-A) metrics and myopia progression in children. METHODS. This prospective, longitudinal cohort study recruited children ages 6 to 8 years for 2- to 6-year follow-ups. OCT-A captured macular images from the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Annual progression of spherical equivalent (SE) and axial length (AL) was calculated as (SE/AL at last visit – SE/AL at baseline)/follow-up duration. Multivariable linear regression analysis evaluated the associations of OCT-A metrics with SE/AL progression. Restricted cubic spline (RCS) analysis evaluated both linear and nonlinear associations. Holm–Bonferroni correction was applied to account for multiple comparisons. RESULTS. A total of 920 children were analyzed. Multivariable linear regression, adjusted for age, sex, baseline SE/AL, and other covariates, showed that baseline foveal avascular zone (FAZ) circularity was negatively associated with annual AL elongation (β = −0.06; 95% confidence interval [CI], −0.10 to −0.02; adjusted P = 0.045). Similarly, the baseline FAZ circularity was positively associated with annual SE progression (β = 0.15; 95% CI, 0.05–0.26; adjusted P = 0.045). No significant associations were found between OCT-A metrics in the DCP with annual AL/SE progression. Furthermore, RCS analysis demonstrated no significant nonlinear associations between OCT-A metrics and annual AL/SE progression (P for nonlinearity > 0.05). CONCLUSIONS. Baseline FAZ circularity in the SCP was significantly associated with annual AL elongation and annual SE progression in children, suggesting its potential as an imaging biomarker for monitoring myopia progression. ; published_or_final_version |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Investigative Ophthalmology & Visual Science; Investigative Ophthalmology & Visual Science, 2025, v. 66, n. 4; WOS:001479551900004; https://hub.hku.hk/handle/10722/357946; 66 |
| DOI: |
10.1167/iovs.66.4.64 |
| Availability: |
https://hub.hku.hk/handle/10722/357946; https://doi.org/10.1167/iovs.66.4.64 |
| Rights: |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.DF9F53B2 |
| Database: |
BASE |