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Ezetimibe added to statin therapy after acute coronary syndromes

Title:	Ezetimibe added to statin therapy after acute coronary syndromes
Authors:	Cannon, Christopher P.; Blazing, Michael A.; Giugliano, Robert P.; McCagg, Amy; White, Jennifer A.; Theroux, Pierre; Darius, Harald; Lewis, Basil S.; Ophuis, Ton Oude; Jukema, J. Wouter; De Ferrari, Gaetano M.; Ruzyllo, Witold; De Lucca, Paul; Im, KyungAh; Bohula, Erin A.; Reist, Craig; Wiviott, Stephen D.; Tershakovec, Andrew M.; Musliner, Thomas A.; Braunwald, Eugene; Califf; Robert M. Musliner T; Tershakovec A; Gurfinkel E; Aylward P; Tonkin A; Maurer G; Van de Werf F; Nicolau JC; Theroux P; Genest J; Armstrong P; Corbalan R; Isaza D; Spinar J; Grande P; Voitk J; Kesaniemi A; Bassand JP; Farnier M; Darius H; Keltai M; Mathur A; Mittal S; Reddy K; Lewis B; De Ferrari GM; Ophuis TO; Jukema J; White H; Pedersen T; Britto F; Ruzyllo W; Carrageta M; Duris T; Dalby A; Seung KB; Lopez-Sendon J; Dellborg M; Mach F; Guneri S; Parkhomenko A; Brady A; Cannon C; Blazing M; Ballantyne C; de Lemos J; Kleiman N; McGuire DK; Centeno E; Casalins M; Cartasegna L; Beltrano MC; Guerrero R; Fanuele M; Berra F; Egido J; Colombo H; Dellatorre M; Terns P; Blumberg E; Reges P; Azize G; Ramos H; Fernandez R; Carlessi C; Milesi R; Schmuck R; Duronto E; Procopio G; Carlevaro O; Maffeo H; Beloscar J; Viso M; Hominal M; Castoldi M; Bluguermann J; Mauro D; Macin S; Cocco N; Ruiz N; Ricart J; Lozada A; Nani S; Turri D; Fernandez H; Caruso O; Zarandon R; Bono J; Arias V; Allall O; Marino J; Cusimano S; Schygiel P; Buzetti C; Penaloza N; Berli M; Worthley S; Roach A; Chew D; Wright T; Leitch J; Hicks E; Rankin J; Venn-Edmonds C; Lehman R; Morrison H; Shaw J; Mak V; Hii C; Smith K; Cross D; Lilwall L; Nelson G; Loxton A; Horowitz J; Rose J; Steinwender C; Leisch F; Kammler J; Brussee H; Zweiker R; Niederl E; Weihs W; Giorgio G; Lang I; Drexel H; Zanolin D; Hoppe U; Atzenhofer-Baumgartner K; Pichler M; Hainzer D; Eber B; Pichler F; Foeger B; Wechselberger T; Mayr H; Hofer J; Stockenhuber F; Warlits B; Huber K; Egger F; Weidinger F; Ziegler B; Jirak P; Metzler B; Pachinger O; Wanitschek M; Auer J; Grabscheit G; Podczeck-Schweighofer A; Priesnitz T; Frank H; El Allaf D; Marechal P; Roosen J; Joly E; Lefebvre P; Arend C; Sinnaeve P; De Velder L; Hellemans S; Vanhauwaert B; Van Dorpe A; Heyse A; Vantomme C; Striekwold H; Van Den Broeck D; Lancellotti P; Schoors D; Lemoine I; Taeymans Y; De Wolf L; Brike C; Vercauteren S; Tahon S; Vervoort G; Mestdagh I; Pirenne B; Cardinal F; Lips S; Dujardin K; Debrouwer K; Dhooghe G; Holvoet G; van de Borne P; Renard M; De Clippel M; Lesseliers H; Van Miert N; Saraiva J; Vicente C; Rossi P; Dos Santos LB; Duda N; Tognon AP; Serrano C; Gomes FL; Manenti ER; Silveira DS; Maia L; Mouco OM; Paiva M; Antonangelo A; de Souza J; Lino EA; Leães P; Blacher MG; Kormann A; Ultramari FT; Dutra O; Mendelski AM; Morgado S; Ardito W; Greque G; Ardito RV; Pimentel Filho P; Zucchetti C; Alves A; Seabra AM; Mattos M; Miranda LF; Silva D; Uehara RM; Marin Neto J; Schmidt A; Braga J; Rodrigues A; Abrantes J; Pinheiro L; Bodanese L; Magedanz ÉH; Piegas L; Dos Santos ES; Wainstein M; Ribeiro J; Stein R; Marino R; Machado VM; Moraes Junior J; Guimarães S; da Costa FA; Ferraz RF; Albuquerque D; Rocha RM; de Carvalho Moreira R; Dohmann H; Costantini C; Tarastchuk JC; Coelho O; Cirillo W; Sousa A; Almeira AS; Stefanini E; Silva F; Teixeira M; da Cunha C; Précoma D; Facchi TL; Rupka D; Thiessen S; Warnica J; Smith B; Della Siega A; Klinke P; Nelson S; Dion D; Gilbert N; Hui W; Kvill L; Sussex B; Luther A; Dupuis R; Ouimet F; Pandey A; Clarus S; Senaratne M; Ferdinandis H; Mukherjee A; Bozek B; Vizel S; Markov G; Zimmermann R; Stephens W; Tremblay B; Wong G; Uchida N; Brossoit R; Peck C; Van Kieu C; Forgione M; Bata I; Cossett J; Kostuk W; Arnold M; Bone C; Grondin F; Bilodeau N; Gosselin G; David M; Giannoccaro J; Beresford P; Polasek P; Roberts P; Doucet M; Beaudry M; Cheung S; Cleveland T; Bhargava R; McCallum A; Ma P; Morrissette J; Cleveland D; Chadwyn D; Nigro F; Weeks A; Cryderman C; Leader R; Houde G; Rousseau S; Pearce M; Radyk M; Lonn E; Magi A; Lefkowitz C; Sandrin F; Coffin N; Lubelsky B; Coldwell J; Habot J; McPherson C; De Larochelliere R; Roy M; Haichin R; Barber C; Bhesania T; Kitagawa H; To T; Donnelly B; Tymchak W; Harris L; Kouz S; Huynh T; St Jacques B; Lamy A; Rizzo A; Stein J; Childs C; Wong B; Poirier R; Gupta M; Dela Cruz C; Constance C; Gauthier M; Ervin F; Ouellette M; Kokis A; Lemay C; Kwok K; Leung C; Lee D; Nesmith J; Renton J; Syan G; Turek M; Hogan D; Griffin P; Lipson A; Winestock J; Abramson B; Fogel A; Gagne C; Bergeron J; Clarke A; Slipp S; Darcel I; Carling-Chambers L; Kannampuzha P; Pallie S; Krekorian S; Vertes G; Roth S; Lai K; Heath J; Perez L; Arriagada G; Castro P; Villa F; Rodríguez M; Ramos G; Baraona F; Núñez A; García M; Jofre C; Silva P; Lamich R; Yovaniniz P; Escobar E; Dussaubat A; Segura E; Ramirez M; Lapostol C; Palma A; Encina L; Zapata M; Baeza N; Varela P; Pérez L; Jaramillo C; Ruiz S; Sanchez G; Perdomo I; Manzur F; Cohen LE; Velasquez J; Arana C; Alvarez Y; Triana M; Balaguera J; de Salazar D; Rendon N; Botero R; Ruiz A; Saaibi J; Medina J; Jaramillo M; Calderón MJ; Delgado J; Bohorquez R; Medina MF; Herrera M; Rosales D; Mendoza F; Martinez S; Ternera A; Castro R; Baiz A; Martinez M; Orozco A; Suarez M; Fonseca Y; Beltran R; Cepeda M; Jaramillo N; Valenzuela C; Gutierrez M; Sanchez A; Vitovec J; Hlinomaz O; Poloczek M; Mayer O; Veselka J; Vejvoda J; Soucek M; Spac J; Novobilsky K; Srp V; Francek L; Branny M; Sknouril L; Motovska Z; Rohac F; Stankova A; Fiala T; Holub M; Zeman K; Pohludkova L; Pospisilova E; Tuma P; Cihalik C; Oral I; Podpera I; Stepanovova R; Uricar M; Solar M; Pelouch R; Porzer M; Grussmannova K; Stipal R; Reichert P; Hradec J; Kral J; Sejkova B; Janek B; Pitha J; Linhart A; Polacek P; Koeber L; Clemmensen P; Hebin CH; Schmidt E; Pedersen MS; Roseva-Nielsen N; Kristensen K; Bang-Hansen T; Jensen J; Laage-Petersen J; Nielsen H; Stokholm E; Thayssen P; Cappelen H; Jensen T; Winther-Friis B; Klausen I; Hedegaard B; May O; Andersen M; Bottzauw J; Lush A; Markenvard J; Vestager KM; Bronnum-Schou J; Hempel H; Petersen J; Nielsen AJ; Thomsen K; Nielsen T; Nygaard A; Sykulski R; Jensen BS; Ralfkiaer N; Gottschalck H; Rasmussen S; Pedersen LR; Dodt K; Skovsbøl M; Andersen O; Tuxen C; Meier AW; Kristensen T; Rasmussen O; Lopez J; Salazar D; Sanchez L; Rosero F; Penaherrera E; Duarte YC; Marmol R; Andrade G; Guzman E; Morillo A; Aug L; Loogna I; Laanmets P; Mustonen J; Mäntylä P; Kesäniemi A; Ukkola O; Kervinen H; Juhela S; Juvonen J; Toppinen A; Jarvenpaa J; Syvanne M; Svahn T; Voutilainen S; Huotari A; Nikkila M; Raiskinmäki S; Kotila M; Rajala A; Laukkanen J; Hiltunen P; Melin J; Nyman K; Luukkonen J; Kosonen P; Huttunen M; Seppänen V; Airaksinen J; Juonala M; Lehto S; Savolainen K; Halkosaari M; Sia J; Palomaki A; Luoma J; Utriainen S; Valpas S; Tiensuu T; Lilleberg J; Kainulainen R; Schiele F; Bassand J; Meneveau N; Galinier M; Jean M; Martelet M; Mouallem J; Elbaz M; Puel J; Carrié D; Coisne D; Varroud-Vial N; Jaboureck O; Dujardin J; Leroy F; Mansourati J; Funck F; Jourdain P; Guillard N; Coviaux F; Gay A; Dourmap-Collas C; Froger-Bompas C; Paillard F; Tricot O; Maquin-Mavier I; Dubois-Rande JL; Pongas D; Paris AP; Delahaye F; Ovize M; Benyahya L; Bonnet J; Belle L; Mangin L; Lafitte B; Zemour G; Doux N; Agraou B; El Mansour N; Traisnel G; El Jarroudi M; Ohlmann P; Diadema B; Escande M; Legros G; Demarcq JM; Haftel Y; Alsagheer S; 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Contributors:	Cannon, Christopher P.; Blazing, Michael A.; Giugliano, Robert P.; Mccagg, Amy; White, Jennifer A.; Theroux, Pierre; Darius, Harald; Lewis, Basil S.; Ophuis, Ton Oude; Jukema, J. Wouter; De Ferrari, Gaetano M.; Ruzyllo, Witold; De Lucca, Paul; Im, Kyungah; Bohula, Erin A.; Reist, Craig; Wiviott, Stephen D.; Tershakovec, Andrew M.; Musliner, Thomas A.; Braunwald, Eugene; Califf; Robert M., Musliner T; Tershakovec, A; Gurfinkel, E; Aylward, P; Tonkin, A; Maurer, G; Van de Werf, F; Nicolau, Jc; Theroux, P; Genest, J; Armstrong, P; Corbalan, R; Isaza, D; Spinar, J; Grande, P; Voitk, J; Kesaniemi, A; Bassand, Jp; Farnier, M; Darius, H; Keltai, M; Mathur, A; Mittal, S; Reddy, K; Lewis, B; De Ferrari, Gm; Ophuis, To; Jukema, J; White, H; Pedersen, T; Britto, F; Ruzyllo, W; Carrageta, M; Duris, T; Dalby, A; Seung, Kb; Lopez-Sendon, J; Dellborg, M; Mach, F; Guneri, S; Parkhomenko, A; Brady, A; Cannon, C; Blazing, M; Ballantyne, C; de Lemos, J; Kleiman, N; Mcguire, Dk; Centeno, E; Casalins, M; Cartasegna, L; Beltrano, Mc; Guerrero, R; Fanuele, M; Berra, F; Egido, J; Colombo, H; Dellatorre, M; Terns, P; Blumberg, E; Reges, P; Azize, G; Ramos, H; Fernandez, R; Carlessi, C; Milesi, R; Schmuck, R; Duronto, E; Procopio, G; Carlevaro, O; Maffeo, H; Beloscar, J; Viso, M; Hominal, M; Castoldi, M; Bluguermann, J; Mauro, D
Publisher Information:	Massachussetts Medical Society
Publication Year:	2015
Collection:	Sapienza Università di Roma: CINECA IRIS
Subject Terms:	acute coronary syndrome; aged; anticholesteremic agent; azetidine; cardiovascular disease; cholesterol; ldl; double-blind method; drug therapy; combination; ezetimibe; female; human; hydroxymethylglutaryl-coa reductase inhibitor; kaplan-meier estimate; male; middle aged; simvastatin; triglyceride; medicine (all
Description:	BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/26039521; info:eu-repo/semantics/altIdentifier/wos/WOS:000356354600005; volume:372; issue:25; firstpage:2387; lastpage:2397; numberofpages:11; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1150638
DOI:	10.1056/NEJMoa1410489
Availability:	http://hdl.handle.net/11573/1150638; https://doi.org/10.1056/NEJMoa1410489
Rights:	info:eu-repo/semantics/closedAccess
Accession Number:	edsbas.E04B38B6
Database:	BASE