Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.
| Title: | Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions. |
|---|---|
| Authors: | Yulia V Skvortsova; Sofia A Kondratieva; Marina V Zinovyeva; Lev G Nikolaev; Tatyana L Azhikina; Ildar V Gainetdinov |
| Source: | PLoS ONE, Vol 11, Iss 6, p e0156454 (2016) |
| Publisher Information: | Public Library of Science (PLoS) |
| Publication Year: | 2016 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Medicine; Science |
| Description: | Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | http://europepmc.org/articles/PMC4889060?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/f28d7396eddb4e278a7a4c397067bbc5 |
| DOI: | 10.1371/journal.pone.0156454 |
| Availability: | https://doi.org/10.1371/journal.pone.0156454; https://doaj.org/article/f28d7396eddb4e278a7a4c397067bbc5 |
| Accession Number: | edsbas.E04E8D19 |
| Database: | BASE |