| Title: |
An adjustable predictive score of graft survival in kidney transplant patients and the levels of risk linked to de novo donor-specific anti-HLA antibodies. |
| Authors: |
Prémaud, Aurélie; Filloux, Matthieu; Gatault, Philippe; Thierry, Antoine; Buchler, Matthias; Munteanu, Eliza; Marquet, Pierre; Essig, Marie; Rousseau, Annick |
| Contributors: |
Pharmacologie des Immunosuppresseurs et de la Transplantation (PIST); Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service d'Immunologie et immunogénétique CHU Limoges; CHU Limoges; Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL); Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Centre National de la Recherche Scientifique (CNRS); Service de néphrologie et immunologie clinique CHRU Tours; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Service de Néphrologie-Hémodialyse-Transplantation rénale CHU Poitiers; Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Service de Néphrologie, Dialyse, Transplantations CHU Limoges; Service de Pharmacologie, toxicologie et pharmacovigilance CHU Limoges; The Astre database was funded by Roche, Astellas and Sanofi. |
| Source: |
ISSN: 1932-6203. |
| Publisher Information: |
CCSD; Public Library of Science |
| Publication Year: |
2017 |
| Collection: |
Université de Limoges: HAL |
| Subject Terms: |
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences |
| Description: |
International audience ; Most predictive models and scores of graft survival in renal transplantation include factors known before transplant or at the end of the first year. They cannot be updated thereafter, even in patients developing donor-specific anti-HLA antibodies and acute rejection.We developed a conditional and adjustable score for prediction of graft failure (AdGFS) up to 10 years post-transplantation in 664 kidney transplant patients. AdGFS was externally validated and calibrated in 896 kidney transplant patients.The final model included five baseline factors (pretransplant non donor-specific anti-HLA antibodies, donor age, serum creatinine measured at 1 year, longitudinal serum creatinine clusters during the first year, proteinuria measured at 1 year), and two predictors updated over time (de novo donor-specific anti-HLA antibodies and first acute rejection). AdGFS was able to stratify patients into four risk-groups, at different post-transplantation times. It showed good discrimination (time-dependent ROC curve at ten years: 0.83 (CI95% 0.76-0.89). |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28671951; PUBMED: 28671951 |
| DOI: |
10.1371/journal.pone.0180236 |
| Availability: |
https://inserm.hal.science/inserm-01547862; https://inserm.hal.science/inserm-01547862v1/document; https://inserm.hal.science/inserm-01547862v1/file/journal.pone.0180236.pdf; https://doi.org/10.1371/journal.pone.0180236 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E0692F22 |
| Database: |
BASE |