Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC)
| Title: | Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC) |
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| Authors: | Visco V.; Forte M.; Giallauria F.; D'Ambrosio L.; Piccoli M.; Schiattarella G. G.; Mancusi C.; Salerno N.; Cesaro A.; Perrone M. A.; Izzo C.; Loffredo F. S.; Bellino M.; Bertero E.; De Luca N.; Pilichou K.; Calabro P.; Manno G.; De Falco E.; Carrizzo A.; Valenti V.; Castelletti S.; Spadafora L.; Tourkmani N.; D'Andrea A.; Pacileo M.; Bernardi M.; Maloberti A.; Simeone B.; Sarto G.; Frati G.; Perrino C.; Pedrinelli R.; Filardi P. P.; Vecchione C.; Sciarretta S.; Ciccarelli M. |
| Contributors: | Visco, V; Forte, M; Giallauria, F; D'Ambrosio, L; Piccoli, M; Schiattarella, G; Mancusi, C; Salerno, N; Cesaro, A; Perrone, M; Izzo, C; Loffredo, F; Bellino, M; Bertero, E; De Luca, N; Pilichou, K; Calabro, P; Manno, G; De Falco, E; Carrizzo, A; Valenti, V; Castelletti, S; Spadafora, L; Tourkmani, N; D'Andrea, A; Pacileo, M; Bernardi, M; Maloberti, A; Simeone, B; Sarto, G; Frati, G; Perrino, C; Pedrinelli, R; Filardi, P; Vecchione, C; Sciarretta, S; Ciccarelli, M |
| Publisher Information: | Elsevier Ireland Ltd; IE |
| Publication Year: | 2025 |
| Collection: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: | Cardiac rehabilitation; Coronary artery disease; Epigenetic; Heart failure; miRNA; Non-coding RNA |
| Description: | The benefits of cardiac rehabilitation (CR) have been demonstrated in patients after myocardial infarction (MI), and in patients with chronic heart failure (HF). The core components of the CR program include improvement in exercise tolerance and optimization of coronary risk factors (i.e., lipid and lipoprotein profiles, body weight, blood glucose levels, blood pressure levels, and smoking cessation). Indeed, CR has been shown to improve exercise capacity, control of cardiovascular risk factors, quality of life, hospital readmission, and mortality rates. Nonetheless, pre- and clinical CR and exercise training models are an enormous source of potential beneficial mechanisms that can be exploited for cardiac disease therapy. Consequently, in this review, we aim to explore the unique benefits of CR in HF and coronary artery disease, focusing on the epigenetic mechanisms involved and their translational relevance. These mechanisms may represent novel therapeutic targets to promote functional recovery after cardiac injury, and non-coding RNAs could be predictive biomarkers for CR success in patients. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40088953; info:eu-repo/semantics/altIdentifier/wos/WOS:001454726400001; volume:429; issue:15 June 2025; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY; https://hdl.handle.net/10281/550624 |
| DOI: | 10.1016/j.ijcard.2025.133166 |
| Availability: | https://hdl.handle.net/10281/550624; https://doi.org/10.1016/j.ijcard.2025.133166 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.E1215615 |
| Database: | BASE |