| Title: |
The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective |
| Authors: |
Paride Pelucchi; Ettore Mosca; Nika Tomsič; Yossma Waheed; Wendalina Tigani; Alice Chiodi; Aditya Mojumdar; Marco Gerdol; Matteo De March |
| Source: |
International Journal of Molecular Sciences ; Volume 27 ; Issue 2 ; Pages: 574 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2026 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
ATP-ase translocase; fork remodeler; DNA repair; tumour suppressor; cancer |
| Description: |
Human zinc finger Ran-binding protein 3 (ZRANB3) is crucial for DNA damage tolerance (DDT), as it prevents excessive damage, restores fork progression, and ultimately maintains genome stability. This unique and ancient architecture mainly exerts its function during replication fork reversal (RFR) and within the p53/Polι axis; thus, ZRANB3 is considered a tumour suppressor. However, possible additional roles in DNA synthesis and cell metabolism have been proposed. In tumour cells, ZRANB3 gene expression is deregulated, a condition that is frequently associated with poor survival and adverse clinical outcomes. ZRANB3 can be altered by functional mutations, gene copy number alterations, and a combination of the two. Although its mRNA levels typically correlate with p53 expression, this correlation breaks down in the context of p53 mutations and high proliferative activity. This comprehensive review integrates the currently available yet fragmented literature on ZRANB3, both at the gene and protein levels, examines its regulation in cancer development, and discusses the evidence supporting its role as a tumour suppressor and prognostic biomarker. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular Biology; https://dx.doi.org/10.3390/ijms27020574 |
| DOI: |
10.3390/ijms27020574 |
| Availability: |
https://doi.org/10.3390/ijms27020574 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.E1389D4B |
| Database: |
BASE |