| Title: |
Expression of MMP-2, MMP-9 and TIMP-2 in pituitary tumors and their relationship with cavernous sinus invasion |
| Authors: |
Thé B Freire, Ane Caroline; Jallad, Raquel S; Batista, Rafael L; Glezer, Andrea; Machado, Marcio C; Ochman, Gilberto; Cescato, Valter A; Cunha Neto, Malebranche Berardo Carneiro; Frassetto, Fernando P; de Medeiros, Raphael S S; Trarbach, Ericka B |
| Source: |
Endocrine Oncology ; volume 5, issue 1 ; ISSN 2634-4793 |
| Publisher Information: |
Bioscientifica |
| Publication Year: |
2024 |
| Description: |
Objective To evaluate the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-2 (TIMP-2) in pituitary tumors and investigate their correlation with circulating plasma proteins and cavernous sinus invasion. In addition, the Ki-67 index was also assessed. Methods Seventy-four patients (37 females) with pituitary adenomas were included, with preoperative peripheral blood collected in 29 cases. Tumor samples were evaluated for MMP-2, MMP-9, TIMP-2 and Ki-67 expression by immunohistochemistry. Protein plasma was semi-quantitatively detected using a commercial membrane antibody array. Results Sixteen patients presented tumors invading the cavernous sinus. MMP-2 and TIMP-2 were slightly increased in these tumors compared to the noninvasive group, but the difference was not statistically significant. MMP-9 and TIMP-2 plasma concentrations did not correlate with tumor protein expression and also did not differ between the two groups. MMP-2 was not detected in plasma in any case. No statistically significant difference was observed when different tumor subtypes were considered. A significant difference was observed in tumor size (3.4 cm (2.8–4.9) vs 1.9 cm (1.3–2.6); P < 0.001) and in the Ki-67 index (1.8% (0.3–2.5) vs 0.5% (0.2–1.0); P = 0.01) between the invasive and noninvasive groups. Conclusions In this cohort, we found no significant correlation between tissue and plasma levels of MMP-2, MMP-9 and TIMP-2 and cavernous sinus invasion in pituitary tumors. Further investigation is needed to elucidate the potential role of these markers in the invasiveness of pituitary tumors. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1530/eo-24-0037 |
| Availability: |
https://doi.org/10.1530/eo-24-0037; https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0037.xml; https://eo.bioscientifica.com/downloadpdf/journals/eo/5/1/EO-24-0037.xml |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.E13DEEE2 |
| Database: |
BASE |