| Title: |
Prevalence of occult nodal metastases in squamous cell carcinoma of the temporal bone: a systematic review and meta-analysis. |
| Authors: |
Borsetto, Daniele; Vijendren, Ananth; Franchin, Giovanni; Donnelly, Neil; Axon, Patrick; Smith, Matthew; Masterson, Liam; Bance, Manohar; Saratziotis, Athanasios; Polesel, Jerry; Boscolo-Rizzo, Paolo; Tysome, James |
| Publisher Information: |
Springer Nature; //doi.org/10.1007/s00405-022-07399-3 |
| Publication Year: |
2023 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Elective neck dissection; Lymph node metastases; Meta-analysis; Squamous cell carcinoma; Temporal bone carcinoma; Humans; Prevalence; Retrospective Studies; Neck Dissection; Carcinoma; Squamous Cell; Lymphatic Metastasis; Temporal Bone; Neoplasm Staging |
| Description: |
PURPOSE: Primary: To determine the rate of occult cervical metastases in primary temporal bone squamous cell carcinomas (TBSSC). Secondary: to perform a subgroup meta-analysis of the risk of occult metastases based on the clinical stage of the tumour and its risk based on corresponding levels of the neck. METHODS: A systematic review and meta-analysis of papers searched through Medline, Cochrane, Embase, Scopus and Web of Science up to November 2021 to determine the pooled rate of occult lymph node/parotid metastases. Quality assessment of the included studies was assessed through the Newcastle-Ottawa scale. RESULTS: Overall, 13 out of 3301 screened studies met the inclusion criteria, for a total of 1120 patients of which 550 had TBSCC. Out of the 267 patients who underwent a neck dissection, 33 had positive lymph nodes giving a pooled rate of occult metastases of 14% (95% CI 10-19%). Occult metastases rate varied according to Modified Pittsburg staging system, being 0% (0-16%) among 12 pT1, 7% (2-20%) among 43 pT2 cases, 21% (11-38%) among 45 pT3, and 18% (11-27%) among 102 pT4 cases. Data available showed that most of the positive nodes were in Level II. CONCLUSION: The rate of occult cervical metastases in TBSCC increases with pathological T category with majority of nodal disease found in level II of the neck. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/xml; application/pdf; application/zip |
| Language: |
English |
| Relation: |
7399; https://www.repository.cam.ac.uk/handle/1810/344997 |
| DOI: |
10.17863/CAM.92422 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/344997; https://doi.org/10.17863/CAM.92422 |
| Accession Number: |
edsbas.E1AC9D9B |
| Database: |
BASE |