| Title: |
A highly virulent variant of HIV-1 circulating in the Netherlands |
| Authors: |
Wymant, Chris; Bezemer, Daniela; Blanquart, François; Ferretti, Luca; Gall, Astrid; Hall, Matthew; Golubchik, Tanya; Bakker, Margreet; Ong, Swee Hoe; Zhao, Lele; Bonsall, David; de Cesare, Mariateresa; Macintyre-Cockett, George; Abeler-Dörner, Lucie; Albert, Jan; Bannert, Norbert; Fellay, Jacques; Grabowski, M. Kate; Gunsenheimer-Bartmeyer, Barbara; Günthard, Huldrych; Kivelä, Pia; Kouyos, Roger; Laeyendecker, Oliver; Meyer, Laurence; Porter, Kholoud; Ristola, Matti; van Sighem, Ard; Berkhout, Ben; Kellam, Paul; Cornelissen, Marion; Reiss, Peter; Fraser, Christophe; Aubert, V.; Battegay, M.; Bernasconi, E.; Böni, J.; Braun, D.; Bucher, H.; Burton-Jeangros, C.; Calmy, A.; Cavassini, M.; Dollenmaier, G.; Egger, M.; Elzi, L.; Fehr, J.; Fellay, J.; Furrer, H.; Fux, C.; Gorgievski, M.; Günthard, H.; Haerry, D.; Hasse, B.; Hirsch, H.; Hoffmann, M.; Hösli, I.; Kahlert, C.; Kaiser, L.; Keiser, O.; Klimkait, T.; Kouyos, R.; Kovari, H.; Ledergerber, B.; Martinetti, G.; de Tejada, B. Martinez; Marzolini, C.; Metzner, K.; Müller, N.; Nadal, D.; Nicca, D.; Pantaleo, G.; Rauch, A.; Regenass, S.; Rudin, C.; Schöni-Affolter, F.; Schmid, P.; Speck, R.; Stöckle, M.; Tarr, P.; Trkola, A.; Vernazza, P.; Weber, R.; Yerly, S.; van der Valk, M.; Geerlings, S.; Goorhuis, A.; Hovius, J.; Lempkes, B.; Nellen, F.; van der Poll, T.; Prins, J.; Reiss, P.; van Vugt, M.; Wiersinga, W.; Wit, F.; van Duinen, M.; van Eden, J.; Hazenberg, A.; van Hes, A.; Pijnappel, F.; Smalhout, S.; Weijsenfeld, A.; Jurriaans, S.; Back, N.; Zaaijer, H.; Berkhout, B.; Cornelissen, M.; Schinkel, C.; Wolthers, K.; Peters, E.; van Agtmael, M.; Autar, R.; Bomers, M.; Sigaloff, K.; Heitmuller, M.; Laan, L.; Ang, C.; van Houdt, R.; Jonges, M.; Kuijpers, T.; Pajkrt, D.; Scherpbier, H.; de Boer, C.; van der Plas, A.; van den Berge, M.; Stegeman, A.; Baas, S.; Hage de Looff, L.; Buiting, A.; Reuwer, A.; Veenemans, J.; Wintermans, B.; Pronk, M.; Ammerlaan, H.; van den Bersselaar, D.; de Munnik, E.; Deiman, B.; Jansz, A.; Scharnhorst, V.; Tjhie, J.; Wegdam, M.; van Eeden, A.; Nellen, J.; Brokking, W.; Elsenburg, L.; Nobel, H.; van Kasteren, M.; Berrevoets, M.; Brouwer, A.; Adams, A.; van Erve, R.; de Kruijf-van de Wiel, B.; Keelan-Phaf, S.; van de Ven, B.; van der Ven, B.; Murck, J.; de Vries-Sluijs, T.; Bax, H.; van Gorp, E.; de Jong-Peltenburg, N.; de Mendonç̧a Melo, M.; van Nood, E.; Nouwen, J.; Rijnders, B.; Rokx, C.; Schurink, C.; Slobbe, L.; Verbon, A.; Bassant, N.; van Beek, J.; Vriesde, M.; van Zonneveld, L.; de Groot, J.; Boucher, C.; Koopmans, M.; van Kampen, J.; Fraaij, P.; van Rossum, A.; Vermont, C.; van der Knaap, L.; Visser, E.; Branger, J.; Douma, R.; Cents-Bosma, A.; Duijf-van de Ven, C.; Schippers, E.; van Nieuwkoop, C.; van Ijperen, J.; Geilings, J.; van der Hut, G.; van Burgel, N.; Leyten, E.; Gelinck, L.; Mollema, F.; Davids-Veldhuis, S.; Tearno, C.; Wildenbeest, G.; Heikens, E.; Groeneveld, P.; Bouwhuis, J.; Lammers, A.; Kraan, S.; van Hulzen, A.; Kruiper, M.; van der Bliek, G.; Bor, P.; Debast, S.; Wagenvoort, G.; Kroon, F.; de Boer, M.; Jolink, H.; Lambregts, M.; Roukens, A.; Scheper, H.; Dorama, W.; van Holten, N.; Claas, E.; Wessels, E.; den Hollander, J.; El Moussaoui, R.; Pogany, K.; Brouwer, C.; Smit, J.; Struik-Kalkman, D.; van Niekerk, T.; Pontesilli, O.; Lowe, S.; Oude Lashof, A.; Posthouwer, D.; van Wolfswinkel, M.; Ackens, R.; Burgers, K.; Schippers, J.; Weijenberg-Maes, B.; van Loo, I.; Havenith, T.; van Vonderen, M.; Kampschreur, L.; Faber, S.; Steeman-Bouma, R.; Al Moujahid, A.; Kootstra, G.; Delsing, C.; van der Burg-van de Plas, M.; Scheiberlich, L.; Kortmann, W.; van Twillert, G.; Renckens, R.; Ruiter-Pronk, D.; van Truijen-Oud, F.; Cohen Stuart, J.; Jansen, Er.; Hoogewerf, M.; Rozemeijer, W.; van der Reijden, W.; Sinnige, J.; Brinkman, K.; van den Berk, G.; Blok, W.; Lettinga, K.; de Regt, M.; Schouten, W.; Stalenhoef, J.; Veenstra, J.; Vrouenraets, S.; Blaauw, H.; Geerders, G.; Kleene, M.; Kok, M.; Knapen, M.; van der Meché, I.; Mulder-Seeleman, E.; Toonen, A.; Wijnands, S.; Wttewaal, E.; Kwa, D.; van Crevel, R.; van Aerde, K.; Dofferhoff, A.; Henriet, S.; ter Hofstede, H.; Hoogerwerf, J.; Keuter, M.; Richel, O.; Albers, M.; Grintjes-Huisman, K.; de Haan, M.; Marneef, M.; Strik-Albers, R.; Rahamat-Langendoen, J.; Stelma, F.; Burger, D.; Gisolf, E.; Hassing, R.; Claassen, M.; ter Beest, G.; van Bentum, P.; Langebeek, N.; Tiemessen, R.; Swanink, C.; van Lelyveld, S.; Soetekouw, R.; van der Prijt, L.; van der Swaluw, J.; Bermon, N.; Jansen, R.; Herpers, B.; Veenendaal, D.; Verhagen, D.; Lauw, F.; van Broekhuizen, M.; van Wijk, M.; Bierman, W.; Bakker, M.; Kleinnijenhuis, J.; Kloeze, E.; Middel, A.; Postma, D.; Schölvinck, E.; Stienstra, Y.; Verhage, A.; Wouthuyzen-Bakker, M.; Boonstra, A.; de Groot-de Jonge, H.; van der Meulen, P.; de Weerd, D.; Niesters, H.; van Leer-Buter, C.; Knoester, M.; Hoepelman, A.; Arends, J.; Barth, R.; Bruns, A.; Ellerbroek, P.; Mudrikova, T.; Oosterheert, J.; Schadd, E.; van Welzen, B.; Aarsman, K.; Griffioen-van Santen, B.; de Kroon, I.; van Berkel, M.; van Rooijen, C.; Schuurman, R.; Verduyn-Lunel, F.; Wensing, A.; Bont, L.; Geelen, S.; Loeffen, Y.; Wolfs, T.; Nauta, N.; Rooijakkers, E.; Holtsema, H.; Voigt, R.; van de Wetering, D.; Alberto, A.; van der Meer, I.; Rosingh, A.; Halaby, T.; Zaheri, S.; Boyd, A.; Bezemer, D.; van Sighem, A.; Smit, C.; Hillebregt, M.; de Jong, A.; Woudstra, T.; Bergsma, D.; Meijering, R.; van de Sande, L.; Rutkens, T.; van der Vliet, S.; de Groot, L.; van den Akker, M.; Bakker, Y.; El Berkaoui, A.; Bezemer, M.; Brétin, N.; Djoechro, E.; Groters, M.; Kruijne, E.; Lelivelt, K.; Lodewijk, C.; Lucas, E.; Munjishvili, L.; Paling, F.; Peeck, B.; Ree, C.; Regtop, R.; Ruijs, Y.; Schoorl, M.; Schnörr, P.; Scheigrond, A.; Tuijn, E.; Veenenberg, L.; Visser, K.; Witte, E.; van Frankenhuijsen, Maartje; Allegre, Thierry; Makhloufi, Djamila; Livrozet, Jean-Michel; Chiarello, Pierre; Godinot, Mathieu; Brunel-Dalmas, Florence; Gibert, Sylvie; Trepo, Christian; Peyramond, Dominique; Miailhes, Patrick; Koffi, Joseph; Thoirain, Valérie; Brochier, Corinne; Baudry, Thomas; Pailhes, Sylvie; Lafeuillade, Alain; Philip, Gisèle; Hittinger, Gilles; Assi, Assi; Lambry, Véronique; Rosenthal, Eric; Naqvi, Alissa; Dunais, Brigitte; Cua, Eric; Pradier, Christian; Durant, Jacques; Joulie, Aline; Quinsat, Denis; Tempesta, Serge; Ravaux, Isabelle; Martin, Isabelle Poizot; Faucher, Olivia; Cloarec, Nicolas; Champagne, Hélène; Pichancourt, Gilles; Morlat, Philippe; Pistone, Thierry; Bonnet, Fabrice; Mercie, Patrick; Faure, Isabelle; Hessamfar, Mojgan; Malvy, Denis; Lacoste, Denis; Pertusa, Marie-Carmen; Vandenhende, Marie-Anne; Bernard, Noëlle; Paccalin, François; Martell, Cédric; Roger-Schmelz, Julien; Receveur, Marie-Catherine; Duffau, Pierre; Dondia, Denis; Ribeiro, Emmanuel; Caltado, Sabrina; Neau, Didier; Dupont, Michel; Dutronc, Hervé; Dauchy, Frédéric; Cazanave, Charles; Vareil, Marc-Olivier; Wirth, Gaétane; Le Puil, Séverine; Pellegrin, Jean-Luc; Raymond, Isabelle; Viallard, Jean-François; Chaigne de Lalande, Severin; Garipuy, Daniel; Delobel, Pierre; Obadia, Martine; Cuzin, Lise; Alvarez, Muriel; Biezunski, Noemie; Porte, Lydie; Massip, Patrice; Debard, Alexa; Balsarin, Florence; Lagarrigue, Myriam; Prevoteau Du Clary, François; Aquilina, Christian; Reynes, Jacques; Baillat, Vincent; Merle, Corinne; Lemoing, Vincent; Atoui, Nadine; Makinson, Alain; Jacquet, Jean Marc; Psomas, Christina; Tramoni, Christine; Aumaitre, Hugues; Saada, Mathieu; Medus, Marie; Malet, Martine; Eden, Aurélia; Neuville, Ségolène; Ferreyra, Milagros; Sotto, Albert; Barbuat, Claudine; Rouanet, Isabelle; Leureillard, Didier; Mauboussin, Jean-Marc; Lechiche, Catherine; Donsesco, Régine; Cabie, André; Abel, Sylvie; Pierre-Francois, Sandrine; Batala, Anne-Sophie; Cerland, Christophe; Rangom, Camille; Theresine, Nadine; Hoen, Bruno; Lamaury, Isabelle; Fabre, Isabelle; Schepers, Kinda; Curlier, Elodie; Ouissa, Rachida; Gaud, Catherine; Ricaud, Carole; Rodet, Roland; Wartel, Guillaume; Sautron, Carmele; Beck-Wirth, Geneviève; Michel, Catherine; Beck, Charles; Halna, Jean-Michel; Kowalczyk, Jakub; Benomar, Meryem; Drobacheff-Thiebaut, Christine; Chirouze, Catherine; Faucher, Jean-François; Parcelier, François; Foltzer, Adeline; Haffner-Mauvais, Cécile; Hustache Mathieu, Mathieu; Proust, Aurélie; Piroth, Lionel; Chavanet, Pascal; Duong, Michel; Buisson, Marielle; Waldner, Anne; Mahy, Sophie; Gohier, Sandrine; Croisier, Delphine; May, Thierry; Delestan, Mikael; Andre, Marie; Zadeh, Mahsa Mohseni; Martinot, Martin; Rosolen, Béatrice; Pachart, Anne; Martha, Benoît; Jeunet, Noëlle; Rey, David; Cheneau, Christine; Partisani, Maria; Priester, Michèle; Bernard-Henry, Claudine; Batard, Marie-Laure; Fischer, Patricia; Berger, Jean-Luc; Kmiec, Isabelle; Robineau, Olivier; Huleux, Thomas; Ajana, Faïza; Alcaraz, Isabelle; Allienne, Christophe; Baclet, Véronique; Meybeck, Agnès; Valette, Michel; Viget, Nathalie; Aissi, Emmanuelle; Biekre, Raphael; Cornavin, Pauline; Merrien, Dominique; Seghezzi, Jean-Christophe; Machado, Moise; Diab, Georges; Raffi, François; Bonnet, Bénédicte; Allavena, Clotilde; Grossi, Olivier; Reliquet, Véronique; Billaud, Eric; Brunet, Cecile; Bouchez, Sabelline; Morineau-Le Houssine, Pascale; Sauser, Fabienne; Boutoille, David; Besnier, Michel; Hue, Hervé; Hall, Nolwenn; Brosseau, Delphine; Souala, Faouzi; Michelet, Christian; Tattevin, Pierre; Arvieux, Cédric; Revest, Matthieu; Leroy, Helene; Chapplain, Jean-Marc; Dupont, Matthieu; Fily, Fabien; Patra-Delo, Solène; Lefeuvre, Céline; Bernard, Louis; Bastides, Frédéric; Nau, Pascale; Verdon, Renaud; de la Blanchardiere, Arnaud; Martin, Anne; Feret, Philippe; Geffray, Loïk; Daniel, Corinne; Rohan, Jennifer; Fialaire, Pascale; Chennebault, Jean Marie; Rabier, Valérie; Abgueguen, Pierre; Rehaiem, Sami; Luycx, Odile; Niault, Mathilde; Moreau, Philippe; Poinsignon, Yves; Goussef, Marie; Mouton-Rioux, Virginie; Houlbert, Dominique; Alvarez-Huve, Sandrine; Barbe, Frédérique; Haret, Sophie; Perre, Philippe; Leantez-Nainville, Sophie; Esnault, Jean-Luc; Guimard, Thomas; Suaud, Isabelle; Girard, Jean-Jacques; Simonet, Véronique; Debab, Yasmine; Schmit, Jean-Luc; Jacomet, Christine; Weinberck, Pierre; Genet, Claire; Pinet, Pauline; Ducroix, Sophie; Durox, Hélène; Denes, Éric; Abraham, Bruno; Gourdon, Florence; Antoniotti, Odile; Molina, Jean-Michel; Ferret, Samuel; Lascoux-Combe, Caroline; Lafaurie, Matthieu; Colin de Verdiere, Nathalie; Ponscarme, Diane; de Castro, Nathalie; Aslan, Alexandre; Rozenbaum, Willy; Pintado, Claire; Clavel, François; Taulera, Olivier; Gatey, Caroline; Munier, Anne-Lise; Gazaigne, Sandrine; Penot, Pauline; Conort, Guillaume; Lerolle, Nathalie; Leplatois, Anne; Balausine, Stéphanie; Delgado, Jeannine; Timsit, Julie; Tabet, Magda; Gerard, Laurence; Girard, Pierre-Marie; Picard, Odile; Tredup, Jürgen; Bollens, Diane; Valin, Nadia; Campa, Pauline; Bottero, Julie; Lefebvre, Benedicte; Tourneur, Muriel; Fonquernie, Laurent; Wemmert, Charlotte; Lagneau, Jean-Luc; Yazdanpanah, Yazdan; Phung, Bao; Pinto, Adriana; Vallois, Dorothée; Cabras, Ornella; Louni, Françoise; Pialoux, Gilles; Lyavanc, Thomas; Berrebi, Valérie; Chas, Julie; Lenagat, Sophie; Rami, Agathe; Diemer, Myriam; Parrinello, Maguy; Depond, Audrey; Salmon, Dominique; Guillevin, Loïc; Tahi, Tassadit; Belarbi, Linda; Loulergue, Pierre; Zak Dit Zbar, Olivier; Launay, Odile; Silbermann, Benjamin; Leport, Catherine; Alagna, Laura; Pietri, Marie-Pierre; Simon, Anne; Bonmarchand, Manuela; Amirat, Naouel; Pichon, François; Kirstetter, Myriam; Katlama, Christine; Valantin, Marc Antoine; Tubiana, Roland; Caby, Fabienne; Schneider, Luminita; Ktorza, Nadine; Calin, Ruxandra; Merlet, Audrey; Ben Abdallah, Saadia; Weiss, Laurence; Buisson, Martin; Batisse, Dominique; Karmochine, Marina; Pavie, Juliette; Minozzi, Catherine; Jayle, Didier; Castel, Philippe; Derouineau, Jean; Kousignan, Pascale; Eliazevitch, Murielle; Pierre, Isabelle; Collias, Lio; Viard, Jean-Paul; Gilquin, Jacques; Sobel, Alain; Slama, Laurence; Ghosn, Jade; Hadacek, Blanka; Thu-Huyn, Nugyen; Nait-Ighil, Lella; Cros, Agnes; Maignan, Aline; Duvivier, Claudine; Consigny, Paul Henri; Lanternier, Fanny; Shoai-Tehrani, Michka; Touam, Fatima; Jerbi, Saadia; Bodard, Loïc; Jung, Corinne; Goujard, Cécile; Quertainmont, Yann; Duracinsky, Martin; Segeral, Olivier; Blanc, Arnaud; Peretti, Delphine; Cheret, Antoine; Chantalat, Christelle; Dulucq, Marie Josée; Levy, Yves; Lelievre, Jean Daniel; Lascaux, Anne Sophie; Dumont, Cécile; Boue, François; Chambrin, Véronique; Abgrall, Sophie; Kansau, Imad; Raho-Moussa, Mariem; de Truchis, Pierre; Dinh, Aurélien; Davido, Benjamin; Marigot, Dhiba; Berthe, Huguette; Devidas, Alain; Chevojon, Pierre; Chabrol, Amélie; Agher, Nouara; Lemercier, Yvon; Chaix, Fabrice; Turpault, Isabelle; Bouchaud, Olivier; Honore, Patricia; Rouveix, Elisabeth; Reimann, Evelyne; Belan, Alix Greder; Godin Collet, Claire; Souak, Safia; Mortier, Emmanuel; Bloch, Martine; Simonpoli, Anne-Marie; Manceron, Véronique; Cahitte, Isabelle; Hiraux, Emmanuel; Lafon, Erik; Cordonnier, François; Zeng, Ai-Feng; Zucman, David; Majerholc, Catherine; Bornarel, Dominique; Uludag, Agnès; Gellen-Dautremer, Justine; Lefort, Agnès; Bazin, Christine; Daneluzzi, Vincent; Gerbe, Juliette; Jeantils, Vincent; Coupard, Mélissa; Patey, Olivier; Bantsimba, Jonas; Delllion, Sophie; Paz, Pauline Caraux; Cazenave, Benoit; Richier, Laurent; Garrait, Valérie; Delacroix, Isabelle; Elharrar, Brigitte; Vittecoq, Daniel; Bolliot, Claudine; Lepretre, Annie; Genet, Philippe; Masse, Virginie; Perrone, Véronique; Boussard, Jean-Luc; Chardon, Patricia; Froguel, Eric; Simon, Philippe; Tassi, Sylvie; Avettand Fenoel, Véronique; Barin, Francis; Bourgeois, Christine; Cardon, Fanny; Chaix, Marie-Laure; Delfraissy, Jean François; Essat, Asma; Fischer, Hugues; Lecuroux, Camille; Petrov-Sanchez, Ventzislava; Rouzioux, Christine; Saez-Cirion, Asier; Seng, Rémonie; Kuldanek, Kristin; Mullaney, Scott; Young, Carmel; Zucchetti, Antonella; Bevan, Margaret-Ann; Mckernan, Sinead; Wandolo, Emily; Richardson, Celia; Youssef, Elaney; Green, Pippa; Faulkner, Sue; Faville, Rebecca; Herman, Sandra; Care, Christine; Blackman, Helen; Bellenger, Katharine; Fairbrother, Keith; Phillips, Andrew; Babiker, Abdel; Delpech, Valerie; Fidler, Sarah; Clarke, Mindy; Fox, Julie; Gilson, Richard; Goldberg, David; Hawkins, David; Johnson, Anne; Johnson, Margaret; Mclean, Ken; Nastouli, Eleni; Post, Frank; Kennedy, N.; Pritchard, J.; Andrady, U.; Rajda, N.; Donnelly, C.; Mckernan, S.; Drake, S.; Gilleran, G.; White, D.; Ross, J.; Harding, J.; Faville, R.; Sweeney, J.; Flegg, P.; Toomer, S.; Wilding, H.; Woodward, R.; Dean, G.; Richardson, C.; Perry, N.; Gompels, M.; Jennings, L.; Bansaal, D.; Browing, M.; Connolly, L.; Stanley, B.; Estreich, S.; Magdy, A.; O’mahony, C.; Fraser, P.; Jebakumar, S.; David, L.; Mette, R.; Summerfield, H.; Evans, M.; White, C.; Robertson, R.; Lean, C.; Morris, S.; Winter, A.; Faulkner, S.; Goorney, B.; Howard, L.; Fairley, I.; Stemp, C.; Short, L.; Gomez, M.; Young, F.; Roberts, M.; Green, S.; Sivakumar, K.; Minton, J.; Siminoni, A.; Calderwood, J.; Greenhough, D.; Desouza, C.; Muthern, Lisa; Orkin, C.; Murphy, S.; Truvedi, M.; Mclean, K.; Hawkins, D.; Higgs, C.; Moyes, A.; Antonucci, S.; Mccormack, S.; Lynn, W.; Bevan, M.; Fox, J.; Teague, A.; Anderson, J.; Mguni, S.; Post, F.; Campbell, L.; Mazhude, C.; Russell, H.; Gilson, R.; Carrick, G.; Ainsworth, J.; Waters, A.; Byrne, P.; Johnson, M.; Fidler, S.; Kuldanek, K.; Mullaney, S.; Lawlor, V.; Melville, R.; Sukthankar, A.; Thorpe, S.; Murphy, C.; Wilkins, E.; Ahmad, S.; Green, P.; Tayal, S.; Ong, E.; Meaden, J.; Riddell, L.; Loay, D.; Peacock, K.; Blackman, H.; Harindra, V.; Saeed, A.; Allen, S.; Natarajan, U.; Williams, O.; Lacey, H.; Care, C.; Bowman, C.; Herman, S.; Devendra, S.; Wither, J.; Bridgwood, A.; Singh, G.; Bushby, S.; Kellock, D.; Young, S.; Rooney, G.; Snart, B.; Currie, J.; Fitzgerald, M.; Arumainayyagam, J.; Chandramani, S.; Rajamanoharan, S.; Robinson, T.; Taylor, B.; Brewer, C.; Mayr, Christoph; Schmidt, Wolfgang; Speidel, Andrea; Strohbach, Frank; Arastéh, Keikawus; Cordes, Christiane; Stündel, Manfred; Claus, Jörg; Baumgarten, Axel; Carganico, Andreas; Ingiliz, Patrick; Dupke, Stephan; Freiwald, Matthias; Rausch, Michael; Moll, Arend; Schleehauf, Dorothea; Hintsche, Bettina; Klausen, Gerd; Jessen, Heiko; Jessen, Arne; Köppe, Siegfried; Kreckel, Peter; Schranz, Dietmar; Fischer, Klaus; Schulbin, Hubert; Speer, Miriam; Glaunsinger, Tobias; Wicke, Thomas; Bieniek, Bernhard; Hillenbrand, Heribert; Schlote, Frank; Lauenroth-Mai, Elke; Schuler, Christoph; Schürmann, Dirk; Wesselmann, Hans; Brockmeyer, Norbert; Gehring, Peter; Schmalöer, Dirk; Hower, Martin; Spornraft-Ragaller, Petra; Häussinger, Dieter; Reuter, Stefan; Esser, Stefan; Markus, Rudolf; Kreft, Burkhard; Berzow, Dirk; Christl, Andreas; Meyer, Andreas; Plettenberg, Andreas; Stoehr, Albrecht; Graefe, Katrin; Lorenzen, Thore; Adam, Axel; Schewe, Knut; Weitner, Lutwin; Fenske, Stefan; Hansen, Stefan; Stellbrink, Hans-Jürgen; Wiemer, Dorothea; Hertling, Sandra; Schmidt, Reinhold; Arbter, Peter; Claus, Bernd; Galle, Peter; Jäger, Hans; Jä̈gel-Guedes, Eva; Postel, Nils; Fröschl, Monika; Spinner, Christoph; Bogner, Johannes; Salzberger, Bernd; Schölmerich, Jürgen; Audebert, Franz; Marquardt, Ties; Schaffert, Andreas; Schnaitmann, Eiko; Trein, Andreas; Frietsch, Bernhard; Müller, Marcus; Ulmer, Albrecht; Detering-Hübner, Barbara; Kern, Peter; Schubert, Franz; Dehn, Günther; Schreiber, Maria; Güler, Cengiz; Schmidt, Daniel; Meixenberger, Karolin |
| Contributors: |
Big Data Institute; University of Oxford; Stichting HIV Monitoring, Amsterdam; Centre interdisciplinaire de recherche en biologie (CIRB); Labex MemoLife; École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris); Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; European Bioinformatics Institute Hinxton (EMBL-EBI); EMBL Heidelberg; Amsterdam University Medical Centers (Amsterdam UMC); The Wellcome Trust Sanger Institute Cambridge; Nuffield Department of Clinical Medicine Oxford; Karolinska Institutet = Karolinska Institute Stockholm; Karolinska University Hospital Stockholm; Robert Koch Institute Berlin (RKI); Ecole Polytechnique Fédérale de Lausanne (EPFL); Swiss Institute of Bioinformatics Basel; Université de Bâle = University of Basel = Basel Universität (Unibas)-Swiss Institute of Bioinformatics Lausanne (SIB); Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL); Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital Lausanne (CHUV); Université de Lausanne = University of Lausanne (UNIL); Johns Hopkins University Baltimore (JHU); University hospital of Zurich Zurich; Universität Zürich Zürich = University of Zurich (UZH); Helsinki University Hospital Finland (HUS); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS); Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| Source: |
ISSN: 0036-8075. |
| Publisher Information: |
CCSD; American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2022 |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
Auteurs : ATHENA HIV Observational Cohort†, the BEEHIVE Collaboration ; International audience ; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35113714; PUBMED: 35113714 |
| DOI: |
10.1126/science.abk1688 |
| Availability: |
https://hal.science/hal-03835688; https://hal.science/hal-03835688v1/document; https://hal.science/hal-03835688v1/file/Lineage%20Effect%20Paper_V12_WithFigures.pdf; https://doi.org/10.1126/science.abk1688 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.E1D8DF8A |
| Database: |
BASE |