| Title: |
Association of Monocyte Migration Marker CD11b With Pulmonary Function in People Living With HIV. |
| Authors: |
Kuniholm, Mark H; Bramah-Lawani, Mariam; Fitzpatrick, Meghan; Nouraie, Mehdi; Qin, Shulin; Huang, Laurence; Vallejo, Abbe N; Landay, Alan L; Morris, Alison |
| Source: |
JAIDS Journal of Acquired Immune Deficiency Syndromes, vol 86, iss 3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2021 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3204 Immunology (for-2020); HIV/AIDS (rcdc); Clinical Research (rcdc); Sexually Transmitted Infections (rcdc); Infectious Diseases (rcdc); Lung (rcdc); 3 Good Health and Well Being (sdg); Adult (mesh); Biomarkers (mesh); CD11b Antigen (mesh); CD4-Positive T-Lymphocytes (mesh); CD8-Positive T-Lymphocytes (mesh); Cell Differentiation (mesh); Cohort Studies (mesh); Female (mesh); HIV Infections (mesh); Humans (mesh); Lung (mesh); Lung Diseases (mesh); Lymphocyte Activation (mesh); Male (mesh); Middle Aged (mesh); Monocytes (mesh); Phenotype (mesh); Respiratory Function Tests (mesh); Vital Capacity (mesh); T cell; monocyte; HIV |
| Subject Geographic: |
344 - 352 |
| Description: |
BACKGROUND: Maladaptive immune responses contribute to the pathogenesis of many chronic lung diseases. Here, we tested hypotheses that CD4 and CD8 T-cell and monocyte phenotypes are associated with lung function in people living with HIV and those without HIV. METHODS: Markers of T cell differentiation, activation, exhaustion and senescence, and markers of monocyte recruitment and migration were quantified in 142 HIV-positive and 73 HIV-negative participants of the Pittsburgh HIV Lung Cohort. All participants underwent lung function testing. RESULTS: CD4 or CD8 T-cell phenotypes were not associated with measures of lung function in HIV-positive or HIV-negative participants after adjustment for multiple comparisons. In HIV-positive participants, however, the percentage of classical monocytes that were CD11b+ had positive associations at the Bonferroni-adjusted significance threshold of P = 0.05/63 with prebronchodilator and postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio (β = 0.36; P = 0.00003 and β = 0.31; P = 0.0003, respectively). In stratified analyses of n = 87 participants with CD4 ≥ 500 cells/µL, associations of percentage of classical monocytes that were CD11b+ with prebronchodilator and postbronchodilator FEV1/FVC ratio were stronger (β = 0.48 and β = 0.41, for pre- and post-, respectively) than in the entire HIV-positive study population. Significant associations of monocyte phenotypes were not observed in HIV-negative participants after adjustment for multiple comparisons. CONCLUSIONS: CD11b+ expression on classical monocytes is positively associated with FEV1/FVC ratio in people living with HIV including in those with CD4 T-cell recovery. Given the normal surveillance activity of monocytes, such association suggests this monocyte subset may play a role in preservation of pulmonary function in PLWH. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt7fd235x2; https://escholarship.org/uc/item/7fd235x2; https://escholarship.org/content/qt7fd235x2/qt7fd235x2.pdf |
| DOI: |
10.1097/qai.0000000000002544 |
| Availability: |
https://escholarship.org/uc/item/7fd235x2; https://escholarship.org/content/qt7fd235x2/qt7fd235x2.pdf; https://doi.org/10.1097/qai.0000000000002544 |
| Rights: |
public |
| Accession Number: |
edsbas.E21331B8 |
| Database: |
BASE |